Adequate Antibody Response to COVID-19 Vaccine in Patients with Monoclonal Gammopathies and Light Chain Amyloidosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35026018/
doi: 10.1093/labmed/lmab113. Online ahead of print. 1 Department of Laboratory Medicine, University of California, San Francisco, California, US. 2 Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco,...
Conclusion: After receiving a COVID-19 vaccine, most patients with MG produce anti-SARS-CoV-2 antibodies comparable to levels in uninfected vaccinated healthy control patients.
Clonal evolution in patients developing therapy-related myeloid neoplasms following autologous stem cell transplantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35027675/
Clonal hematopoiesis (CH) denotes somatic mutations in genes related to myeloid neoplasms present at any variant allele frequency (VAF). Clonal hematopoiesis is associated with increasing age and with a factor...
Conclusion/Relevance: Our data provide evidence to support the hypothesis that the development of tMN following ASCT is likely instigated by CH present at VAFs as low as 0.5%, detectable years before tMN onset.
Characteristics and Follow-Up of Organizing Pneumonia Associated with Haematological Malignancies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35027840/
This study demonstrates that haematological malignancies may be a cause of OP and that minimal invasive biopsy may be an effective and safe method to confirm the diagnosis. Although OP...
Conclusion: This study demonstrates that haematological malignancies may be a cause of OP and that minimal invasive biopsy may be an effective and safe method to confirm the diagnosis. Although OP associated with haematological malignancies may more frequently develop into severe cases, the OP lesions were steroid-responsive during follow-up.
SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34983615/
doi: 10.1186/s13046-021-02226-9. 1 Toni Stephenson Lymphoma Center, Beckman Research Institute of City of Hope, Duarte, CA, USA. [email protected]. 2 Judy and Bernard Briskin Center for Multiple Myeloma Research, Beckman Research...
Conclusion: Our study proves SUMOylation plays a crucial role in Dex resistance in MM and SUMOylation inhibition appears to be an attractive strategy to advance to the clinic for MM patients.
DOPA-Responsive Tremor Associated With Gammopathy: A Case Report and Literature Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984123/
Tremors have been well-described in association with monoclonal gammopathy. We report a case of a patient with asymmetric hands tremor who responded well to levodopa-carbidopa treatment. Further workup showed an...
Conclusion/Relevance: In this case, we are led to conclude that our patient's tremor was centrally mediated since it responded well to dopamine replacement therapy. However, further study is needed to elucidate the role of dopamine depletion in the pathogenesis of tremors associated with gammopathies.