COVID-19 breakthrough infections, hospitalizations and mortality in fully vaccinated patients with hematologic malignancies: A clarion call for maintaining mitigation and ramping-up research - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35120771/
doi: 10.1016/j.blre.2022.100931. Online ahead of print. 1 Center for Artificial Intelligence in Drug Discovery, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Center for Science, Health, and Society,...
Conclusion: In summary, this study shows that among the fully vaccinated population, patients with HM had significantly higher risk for breakthrough infections compared to patients without cancer and that breakthrough infections in patients with HM were associated with significant clinical outcomes including hospitalizations and mortality.
Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma
Research Article | Reona Sakemura, Mehrdad Hefazi, Elizabeth L. Siegler, Michelle J Cox, Daniel P Larson, Michael J. Hansen, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Erin E Tapper,...
CDK9 inhibitors in multiple myeloma: a review of progress and perspectives - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35092513/
Currently, multiple myeloma is not yet considered a curable disease. Despite the recent advances in therapy, the average patient lifespan is still unsatisfactory. Recently, CDK9 inhibitors emerged as a suitable...
Conclusion/Relevance: Although conclusions should be drawn with due care, obtained reports suggest that including CDK9 inhibitors into the current drug regimen may turn out to be beneficial, especially in poor prognosis patients.
Do patients with haematological malignancies suffer financial burden? A cross-sectional study of patients seeking care through a publicly funded healthcare system - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35063283/
Financial toxicity is present in Australian haematology patients and those at higher risk may be patients of working age, those without private health insurance and patients that have been forced...
Conclusion: Financial toxicity is present in Australian haematology patients and those at higher risk may be patients of working age, those without private health insurance and patients that have been forced to retire early or have become unemployed due to their diagnosis.
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment - Oncogenesis
Source : https://www.nature.com/articles/s41389-022-00380-z
Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support metabolic needs of plasma cells (PCs) even transferring mitochondria. In this...
Conclusion/Relevance: Taken together, our data demonstrated that CXCL12/CXCR4 axis mediates intercellular coupling thus suggesting that the myeloma niche may be exploited as a target to improve and develop therapeutic approaches.