Authors should be complemented on a complex immunogenetic study of the elusive tumor micro environment. Will require confirmation in future studies but an

Key Points
• Conclusion: “Our study describes a novel prognostic IRG [immune-related genes] classifier with strong predictive power in DLBCL. Our findings provide valuable guidance for further analysis of DLBCL pathogenesis and clinical treatment.”
• The investigators developed an immune-related classifier for DLBCL prognosis. The model assessed algorithm-derived differences in overall survival between the low- and high-risk groups by means of the tumor microenvironment (TME) and immune infiltration. Molecular mechanisms explaining the clinical significance of our immune-related classifier and transcription factors were also determined
• According to the authors, “The multi-IRG classifier can effectively allocate patients with DLBCL to groups with different risks. Accordingly, IRGs may complement traditional clinicopathological risk factors to generate a comprehensive prognostic tool. The proposed nomogram incorporating the risk score and existing clinical prognostic predictors might facilitate personalized follow-up and management of patients with DLBCL.”