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4yr

Metabolomic approach to characterize the metabolic phenotypes and varied response to ouabain of diffuse large B-cell lymphoma cells

Metabolomic approach to characterize the metabolic phenotypes and varied response to ouabain of diffuse large B-cell lymphoma cells

Source : https://doi.org/10.1080/10428194.2021.1881513

Abstract Abstract Germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtype diffuse large B-cell lymphoma (DLBCL) showed differential prognosis. Our results suggested that ouabain induced stronger inhibition of growth in Su-DHL4 (GCB), and it triggered obvious apoptosis in Su-DHL4 rather than in OCI-Ly3 (ABC).

  • 4yr
    Most novel therapies affect abc preferentially to the gcb subtype of DLBCL. This line of research holds some promise of understanding how we might further influence the gcb subtype of this disease in the future

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