Integrating CAR-T Cell Therapy Into the Management of DLBCL: What We Are Learning
Source : https://pubmed.ncbi.nlm.nih.gov/38078446/
This review aims to describe the current landscape of CAR-T cells in DLBCL, outline their outcomes and toxicities, and explain the outstanding questions that remain to be addressed.
Open questions are inherent in the salvage and bridge therapy, predictive criteria for response, and persistence of chimeric antigen receptor T-cell therapy after infusion.
Recurrent Mutations in Refractory/Relapsed Diffuse Large B Cell Lymphoma by Targeted Gene Sequencing
Source : https://pubmed.ncbi.nlm.nih.gov/38071955/
Introduction-Whole genome sequencing of diffuse large B-cell lymphoma [DLBCL] has identified recurrent mutations involved in pathogenesis and potentially affecting response to therapy. In this pilot study, a targeted gene panel...
Truncated mutations in NOTCH1, TNFAIP3, and CD58 were associated with poor treatment outcomes. In cases that did not respond to treatment, a high number of mutations were found in EZH2, followed by the DNA-binding domains of TP53 and MYD88.
DLBCL Arising From Indolent Lymphomas: How Are They Different?
Source : https://www.sciencedirect.com/science/article/pii/S0037196323000896?via=ihub
Transformation to diffuse large B-cell lymphoma (DLBCL) is a recognized, but unpredictable, clinical inflection point in the natural history of indole...
Transformed lymphomas remain a major clinical challenge because of the absence of consensus therapeutic approaches to managing these patients, patients with transformation are commonly excluded from clinical trials, and therapeutic options are considerably narrower versus the options for the relapsed indolent entity.
The Clinical Significance of Circulating Lymphocytes Morphology in Diffuse Large B-Cell Lymphoma as Determined by a Novel, Highly Sensitive Microscopy
Source : https://www.mdpi.com/2072-6694/15/23/5611
Chimeric Antigen Receptor T-cell (CAR T) therapy has become the preferable treatment in relapsed/refractory diffuse large B-cell lymphomas (DLBCL) patients. Detection of CAR Ts in peripheral blood smear (PBS) is...
Activated morphology chimeric antigen receptor (CAR) T-cell therapy in peripheral blood smear, detected in specific days, was associated with outcome and therapy-related toxicities, emphasizing that CAR T-cell therapy monitoring requires quantitative, qualitative, and repeated measurements.
Comparative Analysis of Conventional Ultrasound and Shear Wave Elastography Features in Primary Breast Diffuse Large B-Cell Lymphoma
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10698400/
Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare subtype of non-Hodgkin lymphoma that accounts for < 3% of extranodal lymphomas and 1% of breast tumors. Its diagnosis and...
These results showed that patients with higher mean elasticity values had worse OS and PFS than those with lower mean elasticity values, indicating that shear wave elastography has potential prognostic value for primary breast DLBCL.