Skeletal Muscle Index Impacts the Treatment Outcome of Elderly Patients With Diffuse Large B Cell Lymphoma
Source : https://pubmed.ncbi.nlm.nih.gov/38287527/
Sarcopenia is a crucial factor in the physical fitness of elderly individuals. This study investigated the prognostic values of multiple parameters of sarcopenia in association with established prognostic factors in...
This study revealed that SMI is the most appropriate assessment method for evaluating sarcopenia and the critical prognostic factor in OS and PFS of elderly patients with DLBCL.
Curative Intent Therapy for DLBCL in the Elderly
Source : https://pubmed.ncbi.nlm.nih.gov/38206922/
Older patients with aggressive lymphoma are extremely heterogeneous due to the high frequency of functional limitations and comorbidities and to the different biological profiles and clinical behavior of the disease....
Novel agents, either alone or in combination with chemo-immunotherapy, are changing the therapeutic landscape of older patients with aggressive lymphoma, both in first-line therapy and in the setting of the relapsed/refractory disease.
Long-Term Survival in a Patient With Transformation of Waldenström’s Macroglobulinemia Into DLBCL
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10758841/
Waldenström's macroglobulinemia (WM) is a rare slow-growing B-cell lymphoma that is characterized by lymphoplasmacytic bone marrow infiltration and the production of monoclonal immunoglobulin M (IgM) paraprotein. In 5-10% of patients,...
A 69-year-old patient was classified as having intermediate risk with an expected 2-year survival probability of 47% after Waldenström macroglobulinemia transformation into DLBCL. However, after receiving therapy, she unexpectedly exceeded these prognostic indications.
Prediction of Severe Infections in Chronic Lymphocytic Leukemia: a Simple Risk Score to Stratify Patients at Diagnosis
Source : https://link.springer.com/article/10.1007/s00277-024-05625-y
Chronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and...
Analysis revealed that age, IGHV mutational status, Binet stage, and hypogammaglobulinemia were statistically associated with time to first infection in univariate and multivariate analyses.
Autologous Stem Cell Transplant in Fit Patients With Refractory or Early Relapsed Diffuse Large B-Cell Lymphoma That Responded to Salvage Chemotherapy
Source : https://haematologica.org/article/view/haematol.2023.284704
Chimeric antigen receptor T-cell (CAR-T) therapy is the new standard of care in fit patients with refractory or early relapsed diffuse large B-cell lymphoma (DLBCL). However, there may still be...
Post-ASCT survival outcomes of patients with refractory or early relapsed DLBCL appeared reasonable and were particularly favorable in those who required only 1 line of salvage chemotherapy to achieve CR before ASCT.