Role of HDL Cholesterol in Anthracycline-Induced Subclinical Cardiotoxicity: a Prospective Observational Study in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP
Source : https://bmjopen.bmj.com/content/14/2/e074541.long
Objectives Anthracycline-induced cardiotoxicity is a debilitating cardiac dysfunction for which there are no effective treatments, making early prevention of anthracycline-induced subclinical cardiotoxicity (AISC) crucial. High-density lipoprotein cholesterol (HDL-C) plays a...
Higher HDL-C levels may be associated with lower AISC risk in patients with DLBCL treated with R-CHOP.
An Anti-CD19/CTLA-4 Switch Improves Efficacy and Selectivity of CAR T Cells Targeting CD80/86-Upregulated DLBCL
Source : https://pubmed.ncbi.nlm.nih.gov/38340727/
Chimeric antigen receptor T cell (CAR T) therapy is a potent treatment for relapsed/refractory (r/r) B cell lymphomas but provides lasting remissions in only ∼40% of patients and is associated...
The CAR/CCR concept constitutes a promising approach to CAR T-cell treatment of B-cell malignancies with the potential for future scientific studies to investigate its mechanistic intricacies and evaluate its real-world clinical benefits in translational trials.
Flow Cytometry Quantification of Tumor-Infiltrating Lymphocytes to Predict the Survival of Patients With Diffuse Large B-Cell Lymphoma
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10859492/
Our previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable...
The results confirmed that abundant TILs (normal B, T, and NK cells) indicated favorable clinical outcomes.
Primary Bone Lymphoma Masquerading as Multiple Myeloma: Challenges in the Diagnostic Workup of Severe Hypercalcemia
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10848882/
In this case, we explore the diagnostic workup of a patient presenting with symptomatic hypercalcemia. Initially suspected to have multiple myeloma, the diagnostic evaluation instead unveiled non-germinal center (non-GC) diffuse...
Although the bone marrow is involved in ≤30% of cases with typical nodal involvement, primary DLBCL of the bone is a rare entity that accounts for <2% of all lymphomas in adults.
Kaposi Sarcoma Herpesvirus/Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma Characterized by Malignant Ascites: a Case Report
Source : https://pubmed.ncbi.nlm.nih.gov/38342036/
Herein, we report a rare case of Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8)-positive diffuse large B-cell lymphoma (DLBCL), which is characterized by malignant ascites and complex karyotypes. A 72-year-old male...
Within the context of preexisting KSHV/HHV8-associated multicentric Castleman disease, the differential diagnosis of this disorder can be challenging.