Human Endogenous Retroviruses as Epigenetic Therapeutic Targets in TP53-Mutated Diffuse Large B-Cell Lymphoma
Source : https://www.nature.com/articles/s41392-023-01626-x
TP53 mutation (TP53mut) occurs in 10-20% of diffuse large B-cell lymphoma (DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression. It confers resistance to immunochemotherapy, high-dose chemotherapy, autologous...
Our investigation highlights human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse barge B-cell lymphoma.
Atypical Diffuse Large B-Cell Lymphoma, Primary Splenic Lymphoma Variant; a Case Report
Source : https://www.sciencedirect.com/science/article/pii/S2210261223009902?via=ihub
Primary splenic lymphoma (PSL) is characterized by lymphoma involvement confined to the spleen and hilar lymph nodes, without evidence of liver involv...
Primary splenic DLBCL is a rare variant of DLBCL, characterized by exclusive involvement of the spleen.
Genetic Subtype-Guided Immunochemotherapy in Diffuse Large B Cell Lymphoma: the Randomized GUIDANCE-01 Trial
Source : https://www.sciencedirect.com/science/article/pii/S1535610823003203?via=ihub
We report the results of GUIDANCE-01 (NCT04025593), a randomized, phase II trial of R-CHOP alone or combined with targeted agents (R-CHOP-X) guided by...
Our findings highlight the efficacy and safety of R-CHOP-X, a mechanism-based tailored therapy, which dually targeted genetic and microenvironmental alterations in patients with newly diagnosed DLBCL.
Triple Lymphoma and Transformation to Diffuse Large B-Cell Lymphoma Finding at the Time of Diagnosis
In this report, we present the case of a patient with an uncommon triple diagnosis of (1) follicular (nodular) lymphoma, (2) nodular lymphocyte predominant Hodgkin lymphoma, and (3) diffuse large...
The R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy regimen is still the standard method of treatment as it has been shown to be effective in treating follicular lymphoma and nodular lymphocyte predominant Hodgkin lymphoma with and without transformation. However, there is insufficient literature on...
Intravascular Large B-Cell Lymphoma
Source : https://www.hindawi.com/journals/crihem/2023/5596890/
Intravascular large B-cell lymphoma (IVBCL) is a very rare and aggressive subtype of extranodal diffuse large B-cell lymphoma (DLBCL) involving the growth of lymphoma cells within blood vessels of all...
IVBCL is a rare and very aggressive disease with variable presentations and difficulties in timely diagnosis. It should be considered as differential diagnosis even in African patients, and further research remains imperative to better understand this unique non-Hodgkin type of lymphoma.