Targeting Glutamine Metabolism in Prostate Cancer
Source : https://www.imrpress.com/journal/FBE/15/1/10.31083/j.fbe1501002/htm
Glutamine is a conditionally essential amino acid important for cancer cell proliferation through intermediary metabolism leading to de novo synthesis of purine and pyrimidine nucleotides, hexosamine biosytnehsis, fatty acid synthesis...
Conclusions/Relevance: Here, it is important to understand that the tumor microenvironment also plays a role in facilitating glutamine signaling and resultant prostate cancer growth. The druggability of prostate cancer glutamine metabolism is more readily achievable with our greater understanding of tumor metabolism and the advent of selective glutaminase inhibitors that have proven safe and tolerable in early-phase clinical trials.
Recruiting African American Prostate Cancer Survivors for a Population-Based Biobank Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36958853/
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Conclusions: Recruiting African American PC survivors to biobanking research through a cancer registry is feasible. However, the consent rate was low, and existing challenges limit consent and participation. Impact: Strategies for overcoming barriers to informed consent and increasing participation in biospecimen research are needed to address cancer disparities.
The androgen-thyroid hormone crosstalk in prostrate cancer and the clinical implications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36930264/
There is increasing evidence that thyroid hormones (THs) work in an integrative fashion with androgen receptors (ARs) to regulate gonadal differentiation and reproductive function. Studies reveal that THs have interactions...
Conclusions/Relevance: This article aims to review the role of androgen-thyroid hormone crosstalk in PCa and its implication in the clinical management. As life expectancy is growing these days, it can increase the number of patients with PCa and the critical relevance of the disease. In order to gain better knowledge about PCa and to improve the clinical management, it is essential to get better insight into the key factors related to the formation and progression of this cancer.
Outcomes over 20 years performing robot-assisted laparoscopic prostatectomy: a single-surgeon experience - World Journal of Urology
Source : https://link.springer.com/article/10.1007/s00345-023-04346-7
Objective To evaluate a single surgeon's 20-year experience with robotic radical prostatectomy. Methods Patients who had undergone robot-assisted laparoscopic prostatectomy by a single surgeon were identified via an IRB approved...
Conclusions: In this 20-year review of our experience with robotic prostatectomy, complication rates and continence outcomes improved over time, and there was a migration to more advanced disease at the time of surgery.
Difficulties in Defining Oligometastatic Prostate Cancer: Implications for Clinical Trial Accrual and Community Practice Adoption of Metastasis-Directed Therapy Approaches - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36902798/
This research suggests that additional imaging (i.e., at least two independent imaging modalities of a possible metastatic lesion) or tumor board adjudication of imaging findings may be critical to correctly...
Conclusions: This research suggests that additional imaging (i.e., at least two independent imaging modalities of a possible metastatic lesion) or tumor board adjudication of imaging findings may be critical to correctly identify patients appropriate for enrollment in oligometastatic protocols. This should be considered as trials of metastasis-directed therapy for oligometastatic prostate cancer accrue and results are translated to broader oncology practice.
WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36905106/
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Conclusion: WDR3 ubiquitinated USF2 and inhibited its stability, while USF2 interacted with promoter region-binding elements of RASSF1A. USF2 transcriptionally activated RASSF1A, which inhibited the carcinogenic effect of WDR3 overexpression.