PARP inhibitors alone or in combination for prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39184454/
DNA repair genomic aberrations in the Homologous Recombination pathway are identifiable in up to 25% of patients with advanced prostate cancer, making them more likely to benefit from treatment with...
DNA repair aberrations in advanced prostate cancer identify patients for PARPi therapy. Trials show efficacy, but refining biomarkers and understanding resistance are crucial for improved outcomes and treatment combinations.
New Drugs for Targeted Radionuclide Therapy in Metastatic Prostate Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39142998/
Metastatic prostate cancer is a frequent and fatal disease. Targeted radionuclide therapy (TRT) has become a readily available therapeutic option since the approval of [ 177 Lu]Lu-PSMA-617. Various molecules are...
Targeted radionuclide therapy (TRT) for metastatic prostate cancer, including innovations like [177Lu]Lu-PSMA-617, shows promise but requires further clinical trials before routine use.
Transcription Factors in Prostate Cancer: Insights for Disease Development and Diagnostic and Therapeutic Approaches
Source : https://pubmed.ncbi.nlm.nih.gov/38674385/
Transcription factors (TFs) are proteins essential for the regulation of gene expression, and they regulate the genes involved in different cellular processes, such as proliferation, differentiation, survival, and apoptosis. Although...
Understanding transcription factors in prostate cancer reveals critical insights into its development and progression, paving the way for targeted diagnostics and innovative therapeutic strategies to enhance patient outcomes.
Limited research exists on psychological and educational interventions for men on ADT. Effective strategies should be personalized, addressing both physical and psychological HRQoL needs.
Effect of Prostate Cancer Education on Saudi Men: Knowledge, Beliefs, and Screening Intentions
Source : https://pubmed.ncbi.nlm.nih.gov/39068578/
Significant improvements were observed in the intervention group compared to the control group after one month. The mean score for knowledge increased by 7.72 (p = 0.001). Beliefs regarding susceptibility,...
Prostate cancer educational programs effectively enhance knowledge, shift beliefs, and boost screening intentions among Saudi men, promising increased awareness and early detection for reduced prostate cancer burden.