Targeted Anti-Cancer Provascular Therapy Using Ultrasound, Microbubbles, and Nitrite to Increase Radiotherapy Efficacy
Source : https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00510
Hypoxia is an important mechanism of resistance to radiation therapy in many human malignancies including prostate cancer. It has been recently shown that ultrasound targeted microbubble cavitation (UTMC) can increase...
Conclusion/Relevance: In conclusion, UTMC nitrite increased blood flow leading to an increased efficacy of higher doses of RT in our tumor model, warranting further study of this strategy.
Germline variants disrupting microRNAs predict long-term genitourinary toxicity after prostate cancer radiation
Source : https://www.thegreenjournal.com/article/S0167-8140(21)09088-5/fulltext
Given the high effectiveness of definitive treatments for localized prostate cancer, quality of life following treatment is a paramount factor in patient-physician shared decision-making.[1] After definitive radiotherapy, a major quality...
Conclusion: Predictive models using germline mirSNPs have high accuracy for predicting late grade ≥2 GU toxicity after either CF-RT or SBRT, and are unique for each treatment, suggesting that germline predictors of late radiation sensitivity are fractionation-dependent. Prospective studies are warranted to further validate these results.
Rectal Perforation by a Balloon Spacer: A Rare Cause of Rectal Perforation Addressed Endoscopically - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34901449/
Prostate cancer is the second most frequent cancer in men worldwide. Dose escalation is currently the standard of care for the treatment of prostate cancer with radiation therapy. However, the...
Conclusion: The investigation confirmed a rectal perforation by the balloon spacer system.
Long-Term Cognitive Dysfunction in Cancer Survivors
Source : https://www.frontiersin.org/articles/10.3389/fmolb.2021.770413/full
Cancer-related cognitive impairment (CRCI) is a frequent side effect experienced by an increasing number of cancer survivors with a significant impact on their quality of life. Different definitions and means...
Relevance: This review summarizes current literature on CRCI with a focus on long-term effects of different cancer treatments, possible risk factors, mechanisms and promising biomarker
Separation effect and development of implantation technique of hydrogel spacer for prostate cancers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34801769/
The separation, spacer thickness and rectal exclusion from the middle to the apex of the prostate and the laterality of the hydrogel spacer affected the reduction in the rectal dose....
Conclusions: The separation, spacer thickness and rectal exclusion from the middle to the apex of the prostate and the laterality of the hydrogel spacer affected the reduction in the rectal dose. The rectal dose can be further reduced by implanting a spacer on the caudal and the prostate side.