Bone health and therapeutic agents in advanced prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35090339/
Prostate cancer is the most frequent genitourinary tumor worldwide. Maintaining an optimum bone health throughout the natural course of prostate cancer is an important aspect in the management of this...
Conclusion/Relevance: In this context, the aim of this review is to analyse key aspects of bone health and therapies that can prevent the occurrence of SREs throughout the clinical course of prostate cancer, and how to combine them with new available treatments in this setting.
Creation of a protective space between the rectum and prostate prior to prostate radiotherapy using a hydrogel spacer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34974913/
The placement of a polyethylene glycol (PEG) hydrogel spacer is a recently developed technique employed to reduce the radiation dose administered to the rectum during prostate radiotherapy. This procedure has...
Relevance: This review familiarises radiologists with the technique and risks and benefits of the use of transperineal delivery of hydrogel spacers with imaging examples.
The change in management by 18 F-DCFPyL PSMA PET scanning in patients undergoing post-prostatectomy radiotherapy, with early biochemical response outcomes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35058320/
Rationale: Prostate specific membrane antigen (PSMA) tracers have increased sensitivity in detection of prostate cancer compared to conventional imaging. We assessed the management impact of 18 F-DCFPyL PET/CT in patients...
Conclusion: 18F-DCFPyL PET/CT has significant impact to management intent in patients being considered for salvage radiotherapy post-RP with PSA recurrence. Increased detection of disease, particularly in the pelvic lymph nodes resulted in increased pelvic irradiation and concurrent ADT use. Early results in patients who are staged with...
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35058580/
doi: 10.1038/s41391-022-00498-6. Online ahead of print. 1 Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 2 Statistic Core, David Geffen School of Medicine...
Conclusion/Relevance: Two weeks after SBRT, CD68, and CD163 macrophages are significantly increased while CD8 T cells are decreased. SBRT markedly alters the immune environment within prostate cancers.
Radiomics-based prognosis classification for high-risk prostate cancer treated with radiotherapy - Strahlentherapie und Onkologie
Source : https://link.springer.com/article/10.1007/s00066-021-01886-y
Objective The present study aimed to investigate if CT-based radiomics features could correlate to the risk of metastatic progression in high-risk prostate cancer patients treated with radical RT and long-term...
Conclusion: Radiomic features were able to predict the risk of metastatic progression in high-risk prostate cancer. Combining the radiomic features and clinical characteristics can classify high-risk patients into favorable and unfavorable prognostic groups.