MRI-Based Radiotherapy Planning to Reduce Rectal Dose in Excess of Tolerance
Source : https://www.hindawi.com/journals/pc/2022/7930744/
Background and Purpose . Chronic rectal toxicity significantly decreases the quality of life for men who receive radiotherapy for prostate cancer. The most significant predictor of rectal toxicity is rectal...
Conclusions: Using MRI to plan prostate IG-IMRT to a dose of 79.2 Gy reduces the volume of rectum receiving radiation dose in excess of tolerance (70 Gy or more) and should be considered in men who are at high risk for late rectal toxicity and are not good candidates for other rectal sparing techniques such as hydrogel spacer.
Pseudo-T2 mapping for normalization of T2-weighted prostate MRI - Magnetic Resonance Materials in Physics, Biology and Medicine
Source : https://link.springer.com/article/10.1007/s10334-022-01003-9
Objective Signal intensity normalization is necessary to reduce heterogeneity in T2-weighted (T2W) magnetic resonance imaging (MRI) for quantitative analysis of multicenter data. AutoRef is an automated dual-reference tissue normalization method...
Discussion: All AutoRef versions reduced variation in the multicenter data. AutoRefFH pseudo-T2s were closest to experimentally measured T2s.
The 45-month therapy outcomes of permanent seed implantation and radical prostatectomy for prostate cancer patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35150357/
Objective To compare the efficacy and safety-related outcomes after radical prostatectomy (RP) and permanent seed implantation (PI) using iodine-125 seeds in patients with prostate cancer. Method A retrospective analysis of...
Conclusion: Iodine-125 seed implantation significantly shortened the average length of hospital stay and indwelling catheter time compared with RP, and the haemoglobin level was significantly higher in the PI group than in the RP group; however, the maximum urine flow rate was lower after of PI than after RP. These two methods showed similar...
Cellular landscape of tumor microenvironment in prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35146758/
Prostate cancer is still a public heath priority in men and the impact of this disease will be more pronounced with the aging of the world's population. Clinical heterogeneity of...
Conclusion: In this study, we confirmed remarkable tumor tissue remodeling in the development of prostate cancer, and further demonstrated the importance of cancer-related fibroblasts in the biochemical recurrence and metastasis for patients with prostate cancer undergoing radical radiotherapy or prostatectomy. In addition, we found that NRP1,...
Analysis of MRI radiomic pelvimetry and correlation with margin status after robotic prostatectomy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35150217/
With the widespread use of MRI in the initial staging of prostate cancer, automated radiomic analysis could augment the critical data already being accumulated in terms of seminal vesical involvement,...
Conclusions: With the widespread use of MRI in the initial staging of prostate cancer, automated radiomic analysis could augment the critical data already being accumulated in terms of seminal vesical involvement, extracapsular extension, and suspicious lymph nodes as risk factors for postoperative salvage radiation. Such automated data could...