An overview of prostate cancer (PCa) diagnosis: Potential role of miRNAs
Source : https://www.sciencedirect.com/science/article/pii/S1936523322002017?via=ihub
Prostate cancer is the second most frequently diagnosed cancer among men worldwide, with the estimated sixth leading cause of cancer death. Despite major advancements in clinical biology and imaging, digital...
Conclusion/Relevance: The combined utilization of miRNAs with other tests will help patients and clinicians to select the most appropriate personalized treatment and to avoid overdiagnosis and unnecessary biopsies. Future clinical applications of our reported novel miRNAs have a substantial role in the primary diagnosis of prostate cancer to...
Systematic study of the iodinated rectal hydrogel spacer material discrepancy on accuracy of proton dosimetry - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36106986/
The inaccurate CT intensity-based material for iodinated spacer resulted in errors in PT dose calculation. We found that the error was negligible if the iodinated spacer was replaced with water....
Conclusion: The inaccurate CT intensity-based material for iodinated spacer resulted in errors in PT dose calculation. We found that the error was negligible if the iodinated spacer was replaced with water. Water density can be used as a clinically accessible and convenient alternative material override to true spacer material.
Oncological and functional outcomes of men undergoing primary whole gland cryoablation of the prostate: A 20-year experience - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36107496/
Primary whole gland cryoablation is an alternative treatment option to radical prostatectomy and radiotherapy for men with organ-confined prostate cancer. Patients had excellent cancer outcomes 1 years after whole gland...
Single fraction of HDR brachytherapy for prostate cancer: Results of the SiFEPI phase II prospective trial
Source : https://www.ctro.science/article/S2405-6308(22)00069-6/fulltext
The global prostate cancer (PC) incidence rate is 1414259 per year; it is the second most common cancer in men after lung cancer and the fifth in terms of mortality...
Conclusions: Long-term results of the SiFEPI trial show that a single fraction of 20 Gy leads to sub-optimal biochemical control for LR/FIR prostate cancers. The late GU and GI toxicity profile is encouraging, leading to consideration of HDB as a safe irradiation technique.
Epigenetic Coregulation of Androgen Receptor Signaling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36107325/
The androgen receptor (AR) is a ligand-activated transcription factor belonging to the nuclear receptor (NR) superfamily. As with other members of the NR family, transcriptional activity of the AR is...
Relevance: In this chapter we will summarise the functional role of epigenetic coregulators in AR signalling, their dysregulation during prostate cancer progression and the current status of drugs targeting these enzymes.