Conclusions: Our study provides detailed methylome maps of non-lethal and lethal prostate cancer and identifies novel genic regions that distinguish these patient groups. Inclusion of our DNA methylation biomarkers with existing clinicopathological measures improves prognostic models of prostate cancer mortality, and holds promise for clinical...

Conclusions: Metformin use concurrent with ADT was associated with lower risks of mortality in Asian, diabetic patients with PCa.

Relevance: Neurovascular bundle (NVB) and internal pudendal artery (IPA) sparing during magnetic resonance-guided radiotherapy (MRgRT) for prostate cancer aims for preservation of erectile function. Our present workflow involves daily online contouring and re-planning on a 1.5 T MR-linac, as alternative to conventional (rigid) translation-only...

Conclusion: This study does not provide strong evidence for an association of intakes of total protein, protein from different dietary sources or amino acids with prostate cancer risk or mortality. However, our results may suggest some weak positive associations, which need to be confirmed in large-scale, pooled analyses of prospective data.

Relevance: Among the advances detailed in the report are the eight new anticancer therapeutics that were approved by the U.S. Food and Drug Administration (FDA) between August 1, 2021, and July 31, 2022. Several of these groundbreaking therapeutics highlight how researchers are rapidly harnessing the knowledge gleaned from discovery science to...