Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response
Abstract. Non-invasive biomarkers for androgen receptor (AR) pathway activation are urgently needed to better monitor patient response to prostate cancer (PCa) therapies. AR is a critical driver and mediator of...
Conclusions: Here, we studied if [&sup89;Zr]11B6-PET can accurately assess EBRT-induced AR activity. Genetic and human PCa mouse models received EBRT (2-50 Gy) and treatment response was monitored by [89Zr]11B6-
Effectiveness of robust optimization against geometric uncertainties in TomoHelical planning for prostate cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36576418/
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Conclusions: For helical IMRT planning in localized prostate cancer, robust optimization provides benefits over PTV margin–based planning, including better OAR sparing, and increased robustness against systematic patient-setup errors.
CACYBP knockdown inhibits progression of prostate cancer via p53 - Journal of Cancer Research and Clinical Oncology
Source : https://link.springer.com/article/10.1007/s00432-022-04497-x
Purpose Prostate cancer (PC) is one of the most common malignant tumors of genitourinary system in men. CACYCLIN binding protein (CACYBP) is involved in the progression of a variety of...
Conclusions: This study revealed that knockdown of CACYBP inhibited the proliferation, migration and tumorigenicity of PC, which may serve as a potential therapeutic target for the treatment of PC.
The Androgen Regulated lncRNA NAALADL2-AS2 Promotes Tumor Cell Survival in Prostate Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36548180/
Castration resistance is the leading cause of death in men with prostate cancer. Recent studies indicate long noncoding RNAs (lncRNAs) to be important drivers of therapy resistance. The aim of...
Conclusions: Castration resistance is the leading cause of death in men with prostate cancer. Recent studies indicate long noncoding RNAs (lncRNAs) to be important drivers of therapy resistance. The aim of this study was to identify differentially expressed lncRNAs in castration-resistant prostate cancer (CRPC) and to functionally characterize...
Night shift work and risk of aggressive prostate cancer in the Norwegian Offshore Petroleum Workers (NOPW) cohort - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36548214/
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Conclusions: "Long-term exposure to rollover shift work may increase the hazard of aggressive prostate cancer in offshore petroleum workers."