Outcomes over 20 years performing robot-assisted laparoscopic prostatectomy: a single-surgeon experience - World Journal of Urology
Source : https://link.springer.com/article/10.1007/s00345-023-04346-7
Objective To evaluate a single surgeon's 20-year experience with robotic radical prostatectomy. Methods Patients who had undergone robot-assisted laparoscopic prostatectomy by a single surgeon were identified via an IRB approved...
Conclusions: In this 20-year review of our experience with robotic prostatectomy, complication rates and continence outcomes improved over time, and there was a migration to more advanced disease at the time of surgery.
Difficulties in Defining Oligometastatic Prostate Cancer: Implications for Clinical Trial Accrual and Community Practice Adoption of Metastasis-Directed Therapy Approaches - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36902798/
This research suggests that additional imaging (i.e., at least two independent imaging modalities of a possible metastatic lesion) or tumor board adjudication of imaging findings may be critical to correctly...
Conclusions: This research suggests that additional imaging (i.e., at least two independent imaging modalities of a possible metastatic lesion) or tumor board adjudication of imaging findings may be critical to correctly identify patients appropriate for enrollment in oligometastatic protocols. This should be considered as trials of...
WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36905106/
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Conclusion: WDR3 ubiquitinated USF2 and inhibited its stability, while USF2 interacted with promoter region-binding elements of RASSF1A. USF2 transcriptionally activated RASSF1A, which inhibited the carcinogenic effect of WDR3 overexpression.
Transcriptomic Heterogeneity in High-risk Prostate Cancer and Implications for Extraprostatic Disease at Presentation on Prostate-specific Membrane Antigen Positron Emission Tomography - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36870853/
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Conclusions: We found a significant correlation between the risk of having prostate cancer outside the prostate gland on a sensitive scan (based on prostate-specific membrane antigen [PSMA]) at initial staging and the Decipher genetic score. The results warrant further studies on the causal pathways between PSMA scan findings, Decipher scores,...
Decision Regret in Patients with Localised Prostate Cancer: A Systematic Review and Meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36870852/
We looked at how common regret in treatment decisions is after treatment for early-stage prostate cancer and factors linked with this. We found that one in five regret their decision,...
Conclusions: We looked at how common regret in treatment decisions is after treatment for early-stage prostate cancer and factors linked with this. We found that one in five regret their decision, with those who had experienced side effects or were less involved in the decision-making process more likely to have regret. By addressing these,...