Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironment
Source : https://pubmed.ncbi.nlm.nih.gov/37161356/
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive...
We summarised and proposed several key issues and directions on applying single-cell multi-omics and spatial transcriptomics to understand the heterogeneity of prostate cancer. Finally, we discussed single-cell omics trends and future directions in prostate cancer.
The roles of proteases in prostate cancer
Source : https://pubmed.ncbi.nlm.nih.gov/36598826/
Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active...
Roles of proteases in prostate cancer, with a special focus on their regulation by androgens.
Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics
Source : https://pubmed.ncbi.nlm.nih.gov/38093355/
Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are insufficient. The hidden onset and poor efficacy of traditional therapies against metastatic PCa make this disease a heavy...
Prostate cancer-derived extracellular vesicle (PCDEV) proteins show promise in PCa diagnosis, prognosis via liquid biopsy, and therapeutic targeting, enhancing understanding and potential treatments for metastatic PCa.
PROTACs in the Management of Prostate Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/37175108/
Cancer treatments with targeted therapy have gained immense interest due to their low levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have drawn special attention in the development of...
PROTACs represent a promising frontier in prostate cancer therapy, offering targeted protein degradation and overcoming resistance mechanisms. Future research aims to optimize efficacy and expand treatment options in this challenging disease landscape.
Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment
Source : https://pubmed.ncbi.nlm.nih.gov/36675055/
Growing evidence of the microbiome's role in human health and disease has emerged since the creation of the Human Microbiome Project. Recent studies suggest that alterations in microbiota composition (dysbiosis)...
Further investigation on the prostate-related microbiome and large-scale clinical trials testing the efficacy of microbiota modulation approaches may improve patient outcomes while fulfilling the literature gap of microbial-immune-cancer-cell mechanistic interactions.