The State of Intermediate Clinical Endpoints as Surrogates for Overall Survival in Prostate Cancer in 2024 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38664138/
In the past, selection of intermediate clinical endpoints (ICEs) in prostate cancer (PCa) trials largely depended on qualitative assessments; however, the advancing quality of research necessitates a robust correlation with...
This review highlights strong evidence supporting metastasis-free survival as a valid intermediate clinical endpoint in localized prostate cancer, while emphasizing the need for cautious use in advanced disease due to limited data.
The Efficacy and Safety of Metastasis-directed Therapy in Patients with Prostate Cancer: A Systematic Review and Meta-analysis of Prospective Studies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37945451/
Direct treatment of metastases is a promising option for selected prostate cancer patients. It can delay hormone therapy and is being investigated as a way of intensifying treatment at the...
Metastasis-directed therapy (MDT) shows promising outcomes in metastatic prostate cancer, offering favorable progression-free survival, excellent local control, and low toxicity, potentially delaying hormone therapy and intensifying treatment.
Overall Survival and Cancer-Specific Mortality in Patients with Prostate Cancer Undergoing Definitive Therapies: A Narrative Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39337047/
The overall survival (OS) of patients with prostate cancer (PCa) who receive locally definitive therapy is generally better than that of patients who do not receive definitive therapy. There is...
This review highlights the importance of lymphadenectomy in esophageal cancer treatment, discussing its development, current evidence, and the debate between extended versus restricted lymph node dissection for optimal oncological outcomes.
Leiomyoma of the prostate: A case report and literature review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39495968/
Prostate leiomyoma is an extremely rare condition, and the current primary approach for managing prostate smooth muscle tumors involves active patient monitoring, regular evaluations, and timely surgical intervention if clinical...
This case report discusses a rare prostate leiomyoma diagnosed postoperatively, treated with Holmium laser enucleation. The patient showed no recurrence, emphasizing active monitoring and timely surgical intervention for smooth muscle tumors.
Prostate Artery Embolization in the Treatment of Massive Intractable Bleeding from Prostatic Neoplasms: A Case Report and Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38202072/
Lower urinary tract symptoms (LUTS) and hematuria are common symptoms in men with neoplasms, mainly affecting the elderly population. Prostatic arterial embolization (PAE) is a minimally invasive procedure that has...
Prostatic Arterial Embolization (PAE) is a promising minimally invasive treatment for managing LUTS and massive hematuria in elderly men with BPH and prostate cancer, offering a safe alternative to high-risk TURP for patients on anticoagulants or antithrombotics.