Home > Focus Areas > Breast Cancer Connect > Post
  • Saved

3yr
Second-Degree Type 2 Atrioventricular Block Requiring Permanent Cardiac Pacing in Patients on CDK4/6 Inhibitors: Report of Two Cases - PubMed

Second-Degree Type 2 Atrioventricular Block Requiring Permanent Cardiac Pacing in Patients on CDK4/6 Inhibitors: Report of Two Cases - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35957944/

To our knowledge, these are the first cases reported in the literature of new-onset advanced AV blocks in patients under treatment with CDK4/6Is, suggesting the clinical relevance of a more frequent ECG monitoring, besides the QT interval, in these patients.


Conclusion: To our knowledge, these are the first cases reported in the literature of new-onset advanced AV blocks in patients under treatment with CDK4/6Is, suggesting the clinical relevance of a more frequent ECG monitoring, besides the QT interval, in these patients.

  • 3yr
    [~Albert--Dekker--aldekker@ ] I think we don't know that it is a causative association--but as abemaciclib carries an adjuvant indication (and heavy marketing presence on TV!) and ribociclib has demonstrated overall survival (whereas palbociclib has not), it's something to be aware of...
  • 4yr
    how we know it is from CK4/6 and not from whatever other reason?