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4yr
Clinical factors and association with treatment modalities in patients with breast cancer and brain metastases who develop leptomeningeal metastases - Breast Cancer Research and Treatment

Clinical factors and association with treatment modalities in patients with breast cancer and brain metastases who develop leptomeningeal metastases - Breast Cancer Research and Treatment

Source : https://link.springer.com/article/10.1007/s10549-022-06595-3

Purpose Leptomeningeal metastases (LM) are an aggressive complication of metastatic breast cancer (MBC) with brain metastases (BM), with a short survival of weeks to months. Studies suggest that surgical resection of BM may increase the risk of LM, especially in infratentorial metastases.


Conclusion: Among MBC patients with BM, infratentorial BM and visceral liver lesions increase the risk of LM, whereas local treatment modalities such as surgery and radiation do not. These data imply that local treatment strategy should not differ based on potential risk for LM.

  • 4yr
    Agree that prognosis for brain metastases regardless of LMD presence is not good. But this is very reassuring data for physicians and providers that local therapies do not appear to be associated with the development of LMD. Bad prognostic characteristics--e.g. the presence of liver metastases--suggest bad biology.
  • 4yr
    does not really matter. between bad and terrible