Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to study autophagosome-lysosome fusion
Source : https://www.sciencedirect.com/science/article/abs/pii/S0006291X22007252?via=ihub
Abe and Vac induce vacuole-like autolysosome formation. * Abe-/Vac-induced vacuole formation depends on autophagy. * Suppressor and inducer for autolysosome formation modulate the vacuole formation. * PGRN is required for...
Relevance: Abemaciclib (Abe) and vacuolin-1 (Vac) are drugs that suppress the progression of breast cancer and induce characteristic vacuole formation in cells. Since Abe-induced vacuoles have the appearance of autolysosomes, they may be used to examine the formation of autolysosomes.
Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35599231/
The mammalian cell cycle has been extensively studied regarding cancer etiology, progression, and therapeutic intervention. The canonical cell cycle framework is supported by a plethora of data pointing to a...
Conclusion/Relevance: Altered cell cycle states represent one means through which the response to cyclin-dependent kinases (CDK)4/6 inhibitors is increased, and has driven new research into the dystopian plasticity of G1/S control.
Artificial intelligence for prediction of treatment outcomes in breast cancer: Systematic review of design, reporting standards, and bias - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35609495/
1 Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Haematology (DIPO), University of Milan, Milan, Italy....
Conclusion: Development of AI algorithms should involve external and prospective validation, with improved code and data availability to enhance reliability and translation of this promising approach. Protocol registration number: PROSPERO - CRD42022292495.
CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35562811/
These observations provide evidence that CDK4/6 inhibitors can induce expression of surface immune markers MHC-I, B7-2, and ICAM-1 in gammaherpesvirus-infected cell lines and induce virus-specific immunity. They can thus thwart...
Conclusions: These observations provide evidence that CDK4/6 inhibitors can induce expression of surface immune markers MHC-I, B7-2, and ICAM-1 in gammaherpesvirus-infected cell lines and induce virus-specific immunity. They can thus thwart virus-induced immune evasion. These effects, along with their direct effects on KSHV- or EBV-induced...
Effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of abemaciclib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35527301/
doi: 10.1007/s00228-022-03331-0. Online ahead of print. 1 Department of Pharmacy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan. [email protected]. 2 Department of Cellular and Molecular Function Analysis,...
Conclusion: ABCB1 2677G > T/A polymorphism might be a predictor of the pharmacokinetics and tolerability of abemaciclib.