Comparison of Clinical Outcomes Between Low- and High-Risk Groups of Early Breast Cancer Patients Treated with Intraoperative Radiotherapy in Addition to External Beam Radiation: A Multi-Centre Prospective Study - World Journal of Surgery
Source : https://link.springer.com/article/10.1007/s00268-022-06753-0
Background There is a paucity of data on the use of intraoperative radiotherapy (IORT) with low-energy X-rays in Malaysian women with early breast cancer. The aim of this study is...
Conclusions: This study showed that the use of IORT in both low- and high-risk early breast cancers is efficacious and safe with low recurrence rates and an acceptable toxicity profile."
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Albert Dekker3yrsafe and effective is fine but not answered the difference in benefit
What are the views of three key stakeholder groups on extending the breast screening interval for low-risk women? A secondary qualitative analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36305519/
doi: 10.1111/hex.13637. Online ahead of print. 1 School of Health Sciences, Manchester Centre of Health Psychology, Division of Psychology and Mental Health, University of Manchester, Manchester, UK. 2 NIHR Manchester...
Conclusions: A risk-stratified screening programme should consider how best to engage women assessed as having a low risk of breast cancer to ensure mutual trust, balance the practicality of change whilst ensuring acceptability, and carefully develop multilevel inclusive communication strategies."
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Albert Dekker3yrmay be alternative strategies needed
Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage Breast Cancer
Source : https://ascopubs.org/doi/10.1200/JCO.22.01609
BRCA1 and BRCA2 are tumor suppressor genes, which confer cancer susceptibility with one germline defective copy but often require a double defective allele for malignant transformation.
Conclusions: Women who carry a germline mutation in BRCA1/2 must cope with a high lifetime risk of breast and ovarian cancer. Although RRM is often advocated, many carrier women fear its adverse effects and seek alternative preventive options. For carrier patients who are diagnosed with unilateral early-stage BC and forgo mastectomy, BCT is a...
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Albert Dekker3yrmost patients still prefer surgery
Pharmacokinetic study on the co-administration of abemaciclib and astragaloside IV in rats
Source : https://www.tandfonline.com/doi/full/10.1080/13880209.2022.2125539
Abstract The co-administration of abemaciclib and astragaloside IV might occur in the treatment of breast cancer. This study evaluates the interaction between abemaciclib and astragaloside IV in rats and describes...
Conclusions: "Discussion and conclusions: The co-administration of abemaciclib and astragaloside IV induced the increasing systemic exposure of abemaciclib through the inhibition of CYP3A4. Further clinical validations could be carried out according to the study design of the present investigation."
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Albert Dekker3yrwe can cure everything in rats
CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36043521/
In recent years, the incidence rate of breast cancer has increased year by year, and it has become a major threat to the health of women globally. Among all breast...
Conclusion/Relevance: With the discovery of the drug resistance mechanism of CDK4/6 inhibitors, various targeted strategies have been proposed. The present review mainly discusses the mechanism of CDK4/6 inhibitors, drug resistance mechanisms and treatment strategies after resistance.
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Sarah Mougalian, Yale Cancer Center3yrThis is a nice review and lays out a conceptual model for treatment options after progression on CDK4/6i + ET. Area of controversy, for sure, and with more studies like Show More