Effectiveness and Safety of Zercepac and Reference Trastuzumab in the Neoadjuvant Setting for Early-Stage Breast Cancer: A Retrospective Cohort Study
Source : https://www.hindawi.com/journals/jo/2022/9998114/
Aim . Since the high cost of reference trastuzumab limits its clinical application, this study aimed to compare the effectiveness and safety of the Zercepac and reference product trastuzumab in...
Conclusions: Zercepac has similar effectiveness and safety profile compared with reference trastuzumab in neoadjuvant therapy, which provides treatment options for patients with HER2-positive breast cancer.
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Albert Dekker3yrmost biosimilar at least as good if not better
Clinical features of CDK4/6 inhibitor-related interstitial lung disease in patients with breast cancer: a case series study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36373891/
The frequency of CDK4/6 inhibitor-induced interstitial lung disease was higher than that reported in clinical trials. We did not identify any risk factors for the development of interstitial lung disease...
Conclusions: The frequency of CDK4/6 inhibitor-induced interstitial lung disease was higher than that reported in clinical trials. We did not identify any risk factors for the development of interstitial lung disease in this study, and thus, larger studies that include patient predisposition are required."
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Albert Dekker3yrthey were not looking for those or were not yet aware of ILD
Real-world data for the renal safety of abemaciclib combined with bisphosphonate in HR+/HER2- advanced breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36351632/
doi: 10.1111/1759-7714.14715. Online ahead of print. 1 Department of Breast Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and...
Conclusions: This study shows that abemaciclib combined with bisphosphonate would be safe for renal function in HR /HER2- ABC patients with bone metastases.
Synthesis, Characterization, and Cytotoxicity of New Spirooxindoles Engrafted Furan Structural Motif as a Potential Anticancer Agent
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9558703/
A new series of spirooxindoles based on ethylene derivatives having furan aryl moiety are reported. The new hybrids were achieved via [3 + 2] cycloaddition reaction as an economic one-step...
Conclusions:Based on these findings and in continuation of our research program toward the synthesis of multifunctionalized spirooxindole drug skeleton for drug research development, we report here the new spirooxindole system appending the furan structural pharmacophore. The molecular features of the new spirooxindole derivative compound were...
A pan-cancer analysis of copper homeostasis-related gene lipoyltransferase 1: Its potential biological functions and prognosis values
Source : https://www.frontiersin.org/articles/10.3389/fgene.2022.1038174/full
As a key copper homeostasis-related molecule, lipoyltransferase 1 (LIPT1) is an essential enzyme for the activation of mitochondrial 2-ketoacid dehydrogenase, participating in fatty acylation. However, the biological significances of LIPT1...
Conclusions: Taken together, our research could provide a comprehensive overview about the significances of LIPT1 in human pan-cancer progression, prognosis and immune.