Expression of HLA class I is associated with immune cell infiltration and patient outcome in breast cancer - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-24890-3
Downregulation of human leukocyte antigen (HLA) class I is one mechanism of escaping anti-tumor immunity by tumor cells. This study was conducted to compare HLA class I expression in ductal...
Conclusions: This study showed that HLA class I expression increased in association with increased immune cell infiltration during in situ to invasive transition of HR-negative breast cancer, and HLA class I down-regulation had a prognostic value in HR-negative breast cancer.
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Albert Dekker3yrobviously less, immune surveillance
Role of androgen receptor signaling pathway-related lncRNAs in the prognosis and immune infiltration of breast cancer - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-25231-0
Androgen receptor (AR) is strong association with breast cancer (BRCA). We aimed to investigate the effect of the androgen receptor signaling pathway-related long non-coding RNAs (ARSP-related lncRNAs) on the process...
Conclusions: The risk score and cluster subtypes were analyzed to study the sensitivity of the patients toward different drugs to identify the appropriate therapeutic agents. The prognoses of patients suffering from BRCA can be accurately predicted by ARSP-related lncRNAs.
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Albert Dekker3yrIs this going to be Oncotype Dx for Triple negative Dx
Tumor infiltrating lymphocytes profile and response in neoadjuvant chemotherapy-treated triple-negative breast carcinoma patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36412444/
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Conclusions: TIL profile with low CD3, CD4, CD20, and CD56 expression predicts PR to NACT in TNBC and may thus help in prognostication of these patients.
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Albert Dekker3yrI am lost what they have tried to tell us. Is it useful or not
Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36467403/
Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4 + T helper 2 cells block early carcinogenesis by...
Acute inflammatory response to multiple chemotherapy regimen in breast carcinoma: An unreported entity 1 - IOS Press
Source : https://content.iospress.com/articles/breast-disease/bd220007
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Conclusions: We report the case of a 53-year lady with locally advanced, hormone receptor-positive, and human epidermal growth factor-2 (HER-2) negative right breast carcinoma