Prognostic Impact of HER2-Low Positivity in Patients With HR-Positive, HER2-Negative, Node-Positive Early Breast Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/37952045/
Adjuvant therapy for patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer (EBC) remains challenging. The prognostic significance of HER2-low positivity in these...
This study investigated the impact of HER2 expression level on the prognosis of patients with HR-positive, HER2-negative, node-positive EBC stratified by recurrence risk. The results revealed that patients with HER2-low had significantly more favorable IDFS and DRFS than patients with HER2-zero in the high recurrence-risk group (i.e., in...
Predicting Early Breast Cancer Recurrence From Histopathological Images in the Carolina Breast Cancer Study
Source : https://www.nature.com/articles/s41523-023-00597-0
Approaches for rapidly identifying patients at high risk of early breast cancer recurrence are needed. Image-based methods for prescreening hematoxylin and eosin (H&E) stained tumor slides could offer temporal and...
We leveraged deep learning to extract image information and trained a model to identify recurrence. Cross-validation accuracy for predicting recurrence was 62.4% [95% CI: 55.7, 69.1], similar to grade (65.8% [95% CI: 59.3, 72.3]) and ER status (66.3% [95% CI: 59.8, 72.8]). Interestingly, 70% (19/27) of early-recurrent low-intermediate grade...
The Role of Matrix Stiffness in Breast Cancer Progression: a Review
Source : https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1284926/full
The significance of matrix stiffness in cancer development has been investigated in recent years. The gradual elastic force the extracellular matrix imparts to cells, known as matrix stiffness, is one...
This review describes the mechanical microenvironment in breast cancer, the effect of extracellular matrix stiffness on breast cancer’s biologic behavior and signaling pathway, and transformation treatments for matrix stiffness in breast cancer.
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Albert Dekker2yrthis has been in discussion for last 20 years
Research Progress of Claudin-Low Breast Cancer
Source : https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1226118/full
Claudin-low breast cancer (CLBC) is a subgroup of breast cancer discovered at the molecular level in 2007.
This article describes the clinicopathologic features of CLBC, which is highly expressed in the immune response, breast cancer stem cells/tumor initiating cells, and EMT-related gene markers.
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Albert Dekker2yrdata in gastric cancer are rather promising
Real-World Analysis of Clinical and Demographic Characteristics, Treatment Patterns, and Outcomes in Predominantly Older Patients with HR+/HER2- Metastatic Breast Cancer Receiving Abemaciclib in Routine Clinical Practice
Source : https://pubmed.ncbi.nlm.nih.gov/37775689/
These patients were older than those in the MONARCH studies with substantial visceral disease, and prior chemotherapy and CDK4 & 6i use. Discontinuation rates were higher than in previous real-world...
These patients were older than those in the MONARCH studies with substantial visceral disease, and prior chemotherapy and CDK4 & 6i use. Discontinuation rates were higher than in previous real-world studies (11.9%), highlighting the need for proactive management to optimize outcomes, particularly in older patients with mBC.
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Albert Dekker2yrVerzenio is not easy and for the older patients in particular