The data from the monarcHER study suggest that the combination of abemaciclib, trastuzumab, and fulvestrant may offer a chemotherapy-free option for patients with HR+, HER2+ ABC who have experienced worsening of disease despite multiple prior therapies.
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Albert Dekker2yrTreatment of ER+/Her2+ tumors is an area of the major unmet need, This approach is likely to be useful and there is article to help to secure insurance coverage
Indirect Treatment Comparison of First-Line CDK4/6-Inhibitors in Post-Menopausal Patients With HR+/HER2- Metastatic Breast Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/37760527/
CDK4/6-inhibitors have demonstrated similar efficacy and are considered an effective first-line endocrine treatment of patients with hormone-receptor positive (HR+)/human-epidermal-growth-factor-receptor-2 negative (HER2-) metastatic breast cancer (MBC) in the endpoint of progress...
Findings from this indirect treatment comparison suggest no significant PFS or OS differences between CDK4/6-inhibitors in postmenopausal patients with HR+/HER2- MBC.
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Albert Dekker2yrvery nice; I always suspected so, but Verzenio is more toxic
Cost-Effectiveness Analysis of Abemaciclib With Endocrine Therapy (ET) Versus ET Alone for HR+, HER2−, Node-Positive, High-Risk Early Breast Cancer in Italy
Source : https://journals.aboutscience.eu/index.php/grhta/article/view/2561
US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status.
Abemaciclib plus ET is a cost-effective treatment option vs ET alone for those with HR+, HER2− node-positive EBC at high risk of recurrence in Italy.
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Albert Dekker2yrif EU feels it is cost effective it may be. I am not sure how different is the price of Verzenio in EU vs US. it very well could be Show More
Single-Cell Transcriptomics Provide Insight into Metastasis-Related Subsets of Breast Cancer
Source : https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-023-01728-y
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more complex interactions between metastatic cancer cells and other cells in...
This study takes single-cell analysis as the first perspective to deeply explore special or rare cell subpopulations related to breast cancer metastasis, systematically summarizes their functions, molecular features, and corresponding treatment strategies, which will contribute to accurately identify, understand, and target tumor...
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Albert Dekker2yrrecent classification changes make it more confusing than helpful
Association Between NDRG1 Protein Expression and Aggressive Features of Breast Cancer: a Systematic Review and Meta-Analysis
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11517-7
Background N-myc downstream-regulated gene-1 (NDRG1) is well-described as a potent metastasis suppressor, but its role in human breast cancer remains controversial and unclear. Therefore, the present study utilized a systematic...
The study concluded that increased NDRG1 protein expression was associated with increased metastasis of the tumor to the axillary lymph node. Additionally, increased NDRG1 protein expression was observed in Her2-negative breast cancer, suggesting its role in both less aggressive and more aggressive behavior depending on breast cancer...
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Albert Dekker2yrdoes anyone know if this gene is a part of oncotypeDX or similar panels?