Mechanism of CDK4/6 Inhibitor Resistance in Hormone Receptor-Positive Breast Cancer and Alternative Treatment Strategies
Source : https://pubmed.ncbi.nlm.nih.gov/38030174/
Breast cancer (BC) is a common malignancy in women, with hormone receptor (HR)-positive subtype responsible for approximately 70% of cases. Currently, patients with metastatic HR-positive BC rely on endocrine therapy...
CDK4/6 inhibitors are currently the effectual standard therapy in combination with endocrine therapy in HR-positive breast cancer. Despite that, issues regarding resistance to CDK4/6 inhibitors in a clinical setting is an inevitable issue.
Should Patients With Hormone Receptor-Positive, HER2-Negative Breast Cancer and One or Two Positive Sentinel Nodes Undergo Axillary Dissection to Determine Candidacy for Adjuvant Abemaciclib?
Source : https://pubmed.ncbi.nlm.nih.gov/38018862/
Patients with one +SLN without HRFs are unlikely to have ≥4 +LNs and should not be subjected to the morbidity of ALND in order to inform candidacy for abemaciclib.
Patients with one +SLN without HRFs are unlikely to have ≥4 +LNs and should not be subjected to the morbidity of ALND to inform candidacy for abemaciclib.
Vaginal CO2 Laser Therapy for Genitourinary Syndrome in Breast Cancer Survivors-VagLaser Study Protocol: a Randomized Blinded, Placebo-Controlled Trial
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11656-x
Vaginal CO2 laser therapy is a new treatment option for genitourinary syndrome of menopause. Its potential is particularly interesting in breast cancer survivors, where existing treatment options often are insufficient...
This study will be the first to investigate change in vaginal and urine microbiota during vaginal laser therapy in survivors of breast cancer.
Machine Learning-Based Models for the Prediction of Breast Cancer Recurrence Risk
Source : https://bmcmedinformdecismak.biomedcentral.com/articles/10.1186/s12911-023-02377-z
Breast cancer is the most common malignancy diagnosed in women worldwide. The prevalence and incidence of breast cancer is increasing every year; therefore, early diagnosis along with suitable relapse detection...
CA125 expression levels affected the risk of recurrence, with higher expression levels associated with a higher five-year risk of recurrence and a shorter progression-free survival in patients.
The Relation Between Excess Adiposity and Breast Cancer in Women: Clinical Implications and Management
Source : https://www.sciencedirect.com/science/article/pii/S1040842823003013?via=ihub
Breast cancer (BC) is the most common cancer in women. While the combination of improved screening, earlier detection, and advances in therapeutics ha...
Weight gain prevention and weight loss interventions should ideally be seamlessly included in the management of breast cancer to provide a holistic, individualized approach to improve health and survival in this population.