In hormone receptor-positive early breast cancer, what most guides your adjuvant systemic therapy decisions?
Normalization of CEA, CA15-3, and CA27-29 Tumor Markers Following Single Lung Transplant in a Patient With a History of Early-Stage Breast Cancer and Idiopathic Pulmonary Fibrosis: A Case Report. - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42130281
This unique case report highlights tumor marker normalization after lung transplant in a patient with IPF and prior early-stage breast cancer, suggesting IPF impact.
Normalization of CEA, CA15-3, and CA27-29 post-lung transplant is uniquely reported here, indicating IPF severity impact rather than breast cancer recurrence.
Human factors validation study of an artificial neural network‑based preoperative decision‑support tool for noninvasive lymph node staging (NILS) in women with primary breast cancer (ISRCTN99301435). - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42204510
Explore how the NILS tool aids physicians in evaluating lymph node status, addressing usability challenges and adoption barriers in breast cancer care.
Physicians find the NILS tool user-friendly, identifying usability challenges and adoption barriers in a study with 20 physicians in a simulated clinical environment.
Intraoperative measurement of breast-conserving surgery margins: surgical application - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42249516/
Breast-conserving surgery (BCS) is an effective treatment for early-stage cancer, provided that there is "no ink on tumor" reported in the excised breast specimen. However, approximately 15-35% of patients require...
Review highlights that positive margins after breast-conserving surgery remain common, leading to re-excisions in 15–35% of patients; emerging intraoperative imaging and molecular-guided technologies may improve margin assessment and reduce recurrence risk.
Sulforaphane Synergies with Phytochemicals and Pharmaceuticals: Implications for Healthspan - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42201192/
Sulforaphane, a bioactive isothiocyanate found abundantly in cruciferous vegetables, has attracted significant attention for its chemopreventive and therapeutic potential, particularly in cancer. There is now an abundance of peer-reviewed research...
Review summarizes evidence that sulforaphane, a cruciferous vegetable-derived isothiocyanate, can synergize with anticancer drugs, emerging therapeutics, and other phytochemicals to enhance efficacy, overcome resistance, and modulate oxidative stress, inflammation, apoptosis, and epigenetic pathways relevant to cancer and healthspan.