This prospective clinical trial indicated a reduced risk of breast cancer after bariatric surgery in women with obesity. The surgical treatment benefit was predominantly seen in women with hyperinsulinemia.
Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy
Source : https://pubmed.ncbi.nlm.nih.gov/38394476/
Odds of achieving pCR and OS in patients with TNBC appear to be associated with race/ethnicity. Additional research is necessary to understand how race/ethnicity is associated with rates of pCR...
Non-Hispanic Black patients were less likely and Hispanic patients were more likely to achieve pathologic complete response than Non-Hispanic White patients.
Diabetes was associated with lower likelihoods of radiotherapy use, chemotherapy use and completion, and endocrine therapy adherence.
Methodology for Using Real-World Data From Electronic Health Records to Assess Chemotherapy Administration in Women With Breast Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/38635936/
We describe the challenges and approaches to operationalize complex, real-world data to identify intended chemotherapy regimens in large, observational studies. This methodology can improve efficiency of use of large-scale clinical...
A number of factors were associated with requiring abstraction for regimen determination, including decreasing neighborhood household income, earlier diagnosis year, later stage, and nodal status.
Assessment of BRCA1 and BRCA2 Germline Variant Data From Patients With Breast Cancer in a Real-World Data Registry
Source : https://pubmed.ncbi.nlm.nih.gov/38709234/
We identify the most common issues with BRCA1 and BRCA2 testing data entry and suggest approaches to minimize data loss and keep interpretation of clinical significance of variants up to...
In the cohort, White and Black patients were over-represented, whereas non-White Hispanic and Asian patients were under-represented.