Revolutionizing breast cancer treatment: Harnessing the related mechanisms and drugs for regulated cell death (Review)
Source : https://pubmed.ncbi.nlm.nih.gov/38456493/
Breast cancer arises from the malignant transformation of mammary epithelial cells under the influence of various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become...
The review explores cuproptosis, ferroptosis, and pyroptosis in breast cancer, examining their roles in disease progression and drug efficacy, offering insights for novel treatments and research.
HER2 heterogeneity and treatment response-associated profiles in HER2-positive breast cancer in the NCT02326974 clinical trial
Source : https://pubmed.ncbi.nlm.nih.gov/38300710/
BACKGROUNDHER2-targeting therapies have great efficacy in HER2-positive breast cancer, but resistance, in part due to HER2 heterogeneity (HET), is a significant clinical challenge. We previously described that in a phase...
HER2-targeting therapy efficacy is reduced in HER2 heterogeneity (HET) tumors, which show distinct resistance mechanisms. Stratification and downstream ERBB pathway targeting are recommended for HET tumors.
Gender-Specific Genetic Predisposition to Breast Cancer: BRCA Genes and Beyond
Source : https://pubmed.ncbi.nlm.nih.gov/38339330/
Among neoplastic diseases, breast cancer (BC) is one of the most influenced by gender. Despite common misconceptions associating BC as a women-only disease, BC can also occur in men. Additionally,...
Understanding gender-specific genetic factors in breast cancer is crucial for personalized risk assessment and treatment. Distinguishing male and female BC genetics enhances precision in prevention and care strategies.
Prevention, diagnosis and clinical management of hereditary breast cancer beyond BRCA1/2 genes
Source : https://pubmed.ncbi.nlm.nih.gov/38870570/
The detection of germline pathogenic variants (gPVs) in BRCA1/2 and other breast cancer (BC) genes is rising exponentially thanks to the advent of multi-gene panel testing. This promising technology, coupled...
The rise of multi-gene panel testing for breast cancer enhances detection and treatment options but introduces complexities with variants of uncertain significance, highlighting the need for updated clinical guidelines.
Lipid profile in breast cancer: From signaling pathways to treatment strategies
Source : https://pubmed.ncbi.nlm.nih.gov/37993054/
Breast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly increased lipid synthesis and uptake, impact the onset and progression of the disease. However, the influence of lipid...
Lipid metabolism in breast cancer differs by subtype and hormone status, influencing tumor progression and drug resistance, particularly through fatty acid synthesis and membrane composition.