Risk vs. benefit: Bisphosphonates in breast cancer
There's a growing interest in the use of bone-modifying agents, or BMAs, known as bisphosphonates in the cancer patient population. But these agents can cause short- and long-term side effects....
Hormone receptor status influences the impact of body mass index and hyperglycemia on the risk of tumor relapse in early-stage HER2-positive breast cancer patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33948122/
High BMI is associated with worse clinical outcomes in early-stage HR-/HER2+ BC patients treated with trastuzumab-containing adjuvant biochemotherapy, while baseline hyperglycemia could be a predictor of worse RFS in HR+/HER2+...
New insights into patterns of first metastatic sites influencing survival of patients with hormone receptor-positive, HER2-negative breast cancer: a multicenter study of 271 patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33926418/
Single metastases with diffuse lesions could more easily disseminate systemically and progress to multiple metastases, leading to a poor prognosis similar to multiple metastases. Our findings indicate that the reconsideration...
Patient-reported outcomes predict progression-free survival of patients with advanced breast cancer treated with abemaciclib - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33914991/
For the first time, pre-treatment patient-reported outcomes have been shown to be independent prognostic markers for progression-free survival (PFS) in patients diagnosed with HR+/HER2- advanced breast cancer treated with abemaciclib....
Gene expression analysis of MCF7 cell lines of breast cancer treated with herbal extract of Cissampelos pareira revealed association with viral diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/33907720/
The study identified 418 differentially expressed genes (DEGs) using bioinformatics tools. The gene ontology of pathway enrichments employed by GO and KEGG enrichment analyses of down-regulated and up-regulated DEGs were...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • Investigators identified 418 differentially expressed genes (DEGs) in breast cancer cell lines using bioinformatics tools. They found in silico evidence for candidate genes integral for the inhibition, adhesion, Show More