Prescribing Tamoxifen in Patients With Mood Disorders: A Systematic Review of Potential Antimanic Versus Depressive Effects - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34166298/
The present review highlights tamoxifen treatment as a possible trigger of mood symptoms onset or exacerbation in vulnerable patients. Accordingly, patients with a history of mood disorders may require a...
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34099663/
Since their discovery as drivers of proliferation, cyclin-dependent kinases (CDKs) have been considered therapeutic targets. Small molecule inhibitors of CDK4/6 are used and tested in clinical trials to treat multiple...
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Naveed Saleh, MD, MS – Skipta Team5yrKey Points • In the current mechanistic study, investigators developed a method to measure the stability of protein complexes in live cells. Their goal was to ascertain how the function of Show More
The role of CDK4/6 inhibitors in early breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34087775/
The use of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) has proven to be a successful strategy in the treatment of advanced hormone receptor-positive (HR + ) and human epidermal growth factor...
Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34104540/
Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by changes in human leukocyte antigen (HLA) ligands. We investigated...
Iris metastasis from breast cancer successfully treated with Abemaciclib and Letrozole - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34127625/
doi: 10.1097/ICB.0000000000001176. Online ahead of print. 1 Bascom Palmer Eye Institute, University of Miami Miller School of Medicine Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine Moffitt...