Pre-Menopausal Women With Breast Cancers Having High AR/ER Ratios in the Context of Higher Circulating Testosterone Tend to Have Poorer Outcomes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34234742/
Our data in pre-menopausal women with breast cancer suggest that it is not merely the presence or absence of AR expression but the relative activity of ER, as well as...
![Molecular modeling studies of [4-(3 H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors - PubMed](https://static-content-prd.skipta.com/public/skipta/skipta-post/2023-02/pubmed-meta-image_445.png "Molecular modeling studies of [4-(3 H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors - PubMed")
Molecular modeling studies of [4-(3 H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34210159/
Aim: CDK4 is a promising target for breast cancer therapy. This study aimed to explore the structure-activity relationship of CDK4 inhibitor abemaciclib analogs and design potent CDK4 inhibitors for breast...
Clinical trial data and emerging immunotherapeutic strategies: hormone receptor-positive, HER2- negative breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34213658/
While checkpoint inhibitors have been approved in patients with newly metastatic PDL1-positive triple negative breast cancer, similar clinical benefit with immunotherapy alone or in combination with chemotherapy has not been...
-
Naveed Saleh, MD, MS – Skipta Team5yrKey Points • In the current review, authors examined approaches to boost immunotherapeutic activity in HR+, HER2− metastatic breast cancer, including combinations of checkpoint inhibition with chemotherapy, endocrine therapy, PARP inhibitors, Show More
Oligometastatic Breast Cancer: How to Manage It? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34207648/
Breast cancer (BC) is the most frequent cancer among women and represents the second leading cause of cancer-specific death. A subset of patients with metastatic breast cancer (MBC) presents limited...
Systemic therapy for early breast cancer in older adults: current status and prospects - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34183493/
Chemotherapy is beneficial for selected older patients with high-risk, ER-negative EBC. Although its impact on QoL is temporary, preferences, higher risk of toxicity and competing risks need to be carefully...