Management of hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34515904/

Estrogen receptor (ER) is the major driver of most metastatic breast cancers (mBCs). Endocrine therapy (ET) is the most effective treatment for ER + mBC, but its effectiveness is limited...

MicroRNAs as Potential Predictors of Response to CDK4/6 Inhibitor Treatment - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34439268/

2021 Aug 16;13(16):4114. doi: 10.3390/cancers13164114. 1 Department of Clinical Therapeutics, Alexandra Hospital, Medical School, 11528 Athens, Greece. 2 Medical School, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue,...

The impact of tumor detection method on genomic and clinical risk and chemotherapy recommendation in early hormone receptor positive breast cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34509707/

We demonstrated an association between the method of cancer detection and both genomic and clinical risk. Symptomatic breast cancer, especially in young women, remains a poor prognostic factor that should...

Analysis of mutation status and homologous recombination deficiency in tumors of patients with germline BRCA1 or BRCA2 mutations and metastatic breast cancer: OlympiAD - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34500047/

gBRCAm identified in patients with HER2-negative metastatic breast cancer by germline testing in blood was also identified by tumor tissue testing. gsLOH was common, indicating a high rate of biallelic...

Anthracyclines Strike Back: Rediscovering Non-Pegylated Liposomal Doxorubicin in Current Therapeutic Scenarios of Breast Cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34503231/

Anthracyclines are among the most active chemotherapies (CT) in breast cancer (BC). However, cardiotoxicity is a risk and peculiar side effect that has been limiting their use in clinical practice,...