Long-Term Outcomes and Prognostic Factors of Patients with Metastatic Solid Tumors Admitted to the Intensive Care Unit - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35051928/
doi: 10.1159/000520097. Online ahead of print. 1 Department of Medical Oncology, Centre Oscar Lambret, Lille, France. 2 Medical School, Lille University, Lille, France. 3 Department of Medical Oncology, Hôpital Duchesne...
Discussion: In the ICU, the OS of adult patients with solid tumors was similar to that of the noncancer population. For ICU admissions related to the cancer itself, the prognosis is poor.
Updates on breast biomarkers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35029776/
Recent advancements in breast cancer treatment have ushered in a new era of precision medicine. Novel trials have led to the approval of a growing list of personalized therapies and...
Conclusion/Relevance: Understanding the complex algorithms and diagnostic modalities used to assess predictive and prognostic biomarkers is central for quality oncology care. ER and HER2 subcategorize breast cancers into treatment groups under which different biomarkers and therapies are indicated, while they also serve as predictive biomarkers...
Metastasis of breast cancer to the right kidney with a tumor thrombus in the inferior vena cava: a case report - Surgical Case Reports
Source : https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-022-01364-2
Background It is quite rare for breast cancer to metastasize to the kidney with a tumor thrombus in the inferior vena cava. Case presentation A Japanese woman in her forties...
Conclusions: It is sometimes difficult to differentiate between primary renal cancer and kidney metastases from breast cancer on imaging. Renal biopsy is recommended before commencing treatment.
Systematic Review of Molecular Biomarkers Predictive of Resistance to CDK4/6 Inhibition in Metastatic Breast Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35005994/
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have revolutionized the treatment of hormone-positive metastatic breast cancers (mBCs). They are currently established as standard therapies in combination with endocrine therapy as...
Relevance: The rapidly emerging molecular landscape is captured through next-generation sequencing of breast cancers (DNA with or without RNA), liquid biopsies (circulating tumor DNA), and protein analyses. Individual molecular candidates with robust and reliable evidence are discussed in more depth.
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Breast Cancer Connect4yrKey Points • Source: JCO Precision Oncology • Relevance: “We can now identify patient populations that will respond poorly to CDK4/6 inhibition through tumor profiling and next-generation sequencing of liquid biopsies before starting treatment Show More
The 21-gene recurrence score in early non-ductal breast cancer: a National Cancer Database analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35027533/
doi: 10.1038/s41523-021-00368-9. 1 Montefiore Einstein Center for Cancer Care, New York, NY, USA. [email protected]. 2 Albert Einstein Cancer Center, Bronx, NY, USA. 3 Montefiore Einstein Center for Cancer Care, New...
Relevance: The 21-gene recurrence score (RS) is prognostic for recurrence and predictive of chemotherapy benefit in early estrogen receptor-positive (ER ) HER2-negative (HER2-) breast cancer (BCA).