Impact of lobular versus ductal histology on overall survival in metastatic breast cancer: a French retrospective multicentre cohort study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35176614/
doi: 10.1016/j.ejca.2021.12.031. Online ahead of print. 1 Department of Medical Oncology, Institut Claudius Regaud-IUCT Oncopole, Toulouse, France. 2 Department of Biostatistics, Institut Claudius Regaud-IUCT Oncopole, Toulouse, France. 3 Department of...
Conclusion: Lobular histology is an independent adverse prognostic factor among women with MBC. ILC MBC could be considered a specific entity. Dedicated prospective studies are needed to tailor the management of these patients.
Clinical and Molecular Characteristics of ER-Positive Ultralow Risk Breast Cancer Tumors Identified by the 70-Gene Signature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35179782/
The metastatic potential of estrogen receptor (ER)-positive breast cancers is heterogenous and distant recurrences occur months to decades after primary diagnosis. We have previously shown that patients with tumors classified...
Relevance: In conclusion, ultralow risk tumors, associated with minimal long-term risk of fatal disease, differ from other ER-positive tumors, including luminal A molecular subtype tumors. Identification of these characteristics is important to improve our prediction of non-fatal versus fatal breast cancer. This article is protected by...
Update Breast Cancer 2021 Part 4 - Prevention and Early Stages - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35169388/
This past year has seen new and effective options for further improving treatment outcome in many patients with early-stage breast cancer. Patients with hormone receptor-positive disease benefited significantly from the...
Relevance: Patients with hormone receptor-positive disease benefited significantly from the addition of the CDK4/6 inhibitor abemaciclib to endocrine adjuvant therapy.
Recent advances of transcriptomics and proteomics in triple-negative breast cancer prognosis assessment - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35150062/
Triple-negative breast cancer (TNBC), a heterogeneous tumour that lacks the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), is often characterized by...
Conclusion/Relevance: Here, we review the recent progress of TNBC research in transcriptomics and proteomics to identify possible therapeutic goals and improve the survival of patients with triple-negative breast cancer. Also, researchers may benefit from this article to catalyse further analysis and investigation to decipher the global picture...
Receptor conversion and vocal cord paralysis in a patient with breast cancer
Source : https://casereports.bmj.com/content/15/2/e243700.long
Receptor conversion in breast cancer occurs in up to 32% of patients, resulting in ineffective therapy in the absence of corresponding biomarkers. We report a case of a middle-aged woman...
Conclusion/Relevance: Reassessment of receptor status in metastatic breast cancer is encouraged to rule out receptor conversion. There is significant cross-talk between OR and HER2 signalling pathways, leading to treatment resistance. Close collaboration and teamwork among various subspecialties facilitate prompt management of patients with...