Designing Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35200398/
The rising survival rate for early-stage breast cancer in the United States has created an expanding population of women in remission at risk for distant recurrence, with metastatic spread to...
Conclusion/Relevance: We find that metastatic resections demonstrate distinct cellular and matrix components compared with primary resections or non-cancerous controls. Using our model systems, we find that the observed deposition of collagen I after metastasis to the brain may enhance breast cancer invasion. Future optimization of these models...
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Albert Dekker4yrThis is why biopsy at metastatic Dx is required and has different biology
An UHPLC-MS/MS method for quantification of the CDK4/6 inhibitor abemaciclib in human serum
Source : https://www.sciencedirect.com/science/article/pii/S2667145X22000025?via=ihub
2D chromatography: semi-automated sample preparation for abemaciclib. * Biphenyl column: better performance for analyzing abemaciclib. * Wide calibration range to cover individual levels of abemaciclib. * Kinetic data: concentration-time profile...
Conclusions: The novelty of the presented two dimensional isotope dilution UHPLC-MS/MS method is in the semi-automated sample preparation, which results in negligible matrix effects, thereby allowing the introduction of abemaciclib into robust routine therapeutic drug monitoring (TDM). This method provides an efficient tool to verify the...
Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35201661/
doi: 10.1111/cas.15304. Online ahead of print. 1 Cancer Precision Medicine Center, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. 2 Cancer Precision Medicine Inc., Kawasaki, Japan. 3 Breast...
Conclusion: Our findings demonstrated the possible clinical utility of serial ctDNA analysis for earlier progressive disease detection and real-time monitoring of CDK4/6i response.
Mechanistic insights expatiating the biological role and regulatory implications of estrogen and HER2 in breast cancer metastasis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35202768/
Breast cancer (BCa) has become the leading cause of death in women worldwide. Irrespective of advancement in cancer treatments, e.g., surgery, radiation, chemotherapy, hormonal therapy, immunotherapy, and targeted therapy, recurrence...
Relevance: BCa receptors estrogen (ER), progesterone (PR), and human epidermal growth factor receptor-2 (HER2) hold significant reputations as prognostic and predictive biomarkers in therapeutic decision-making.
PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35181669/
We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain (PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR + /HER2-) breast cancer (BC). We analyzed primary...
Relevance: We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain (PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR /HER2-) breast cancer (BC). We analyzed primary HR /HER2- BC from three publicly available datasets comprising over 2000 samples and assessed the associations with tumoral and...
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Breast Cancer Connect4yrKey Points • Source: Circulation Research • Relevance: “We aim to elucidate the prognostic value of PIK3CA mutations and copy number (CN) gain (PIK3CA-mut/gain) in hormone receptor-positive and HER2-negative (HR + /HER2−) breast cancer (BC).” • Investigators assessed Show More