• Saved

December 03, 2022
RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

Source : https://www.sciencedirect.com/science/article/pii/S1672022922001425?via=ihub

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control ratio of non-small cell lung cancer (NSC...

/>

Conclusions: Conclusions/Relevance: Our study reveals an unprecedented mechanism through which the RNA structure switch modulates EGFR-TKI resistance by controlling YRDC mRNA translation in an ELAVL1-dependent manner.

  • December 03, 2022
    I am lost a bit; so RNA is able to b self regulated on mRNA level?