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Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer

Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer

Source :

https://www.hindawi.com/journals/cjgh/2022/5415758/

To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark gene sets from gene set enrichment analysis.


Relevance: In this study, we outlined a novel stratification method including systematic pathway activity changes of gene sets in both tumor tissues and nontumor tissues and provided a more accurate prognostic model based on least absolute shrinkage and selection operator (LASSO) regression for patients with gastric cancer, which might help to improve patient outcomes, to offer suggestions after gastrectomy, and to facilitate personalized therapy in the nearer future.