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Leptin stimulates migration and invasion and maintains cancer stem‑like properties in gastric cancer cells

Leptin stimulates migration and invasion and maintains cancer stem‑like properties in gastric cancer cells

Source :

https://www.spandidos-publications.com/10.3892/or.2022.8377

Obesity is a risk factor for various types of cancer. Leptin, an adipocyte‑derived hormone, may stimulate the proliferation of gastric cancer cells. However, the effect of leptin and underlying mechanism in gastric cancer remain unclear. In the present study, the role of leptin in gastric cancer was evaluated.


Conclusion: The present findings support an adverse effect of obesity in gastric cancer. Consequently, targeting of leptin‑associated signaling pathways may have therapeutic potential for gastric cancer.