Gastric Cancer Connect
July 25, 2022
Key Points
• Source: Scandinavian Journal of Gastroenterology
• Conclusion: “The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk Show More
The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression - PubMed
The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more
68Ga-PSMA Uptake in Brain Metastasis of Gastric Carcinoma - PubMed
A 69-year-old man with a known history of gastric and prostate adenocarcinoma was referred to 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging due to biochemical recurrence of prostate cancer. 68Ga-PSMA ..... see more
Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer
To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more
Source : https://www.hindawi.com/journals/cjgh/2022/5415758/
Relevance: In this study, we outlined a novel stratification method including systematic pathway activity changes of gene sets in both tumor tissues and nontumor tissues and provided a more accurate prognostic model based on least absolute shrinkage and selection operator (LASSO) regression for patients with gastric cancer, which might help to...
Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy - BMC Cancer
Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2
Leptin stimulates migration and invasion and maintains cancer stem‑like properties in gastric cancer cells
Obesity is a risk factor for various types of cancer. Leptin, an adipocyte‑derived hormone, may stimulate the proliferation of gastric cancer cells. However, the effect of leptin and underlying mechanism ..... see more
Source : https://www.spandidos-publications.com/10.3892/or.2022.8377
Pull the plug: Anti-angiogenesis potential of natural products in gastrointestinal cancer therapy - PubMed
Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common malignant tumor originating from the gastrointestinal epithelium. Although the pathogenesis of GIC has not been fully elucidated, angiogenesis ..... see more
The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression - PubMed
The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more
Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer
To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more
Source : https://www.hindawi.com/journals/cjgh/2022/5415758/
The application of new gastric cancer screening score system for gastric cancer screening and risk assessment of gastric precancerous lesions in China - PubMed
Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more
The application of new gastric cancer screening score system for gastric cancer screening and risk assessment of gastric precancerous lesions in China - PubMed
Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more
Conclusions: The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk assessment of gastric precancerous lesions. The role of new gastric cancer screening score system in future gastric precancerous lesions screening and high risk population identifying was promising.
Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019
BackgroundThe burden of care continues to rise considerably worldwide and the challenge of diversity in cancer research has become important. We aimed to examine trends of cancer care utilization and ..... see more
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.862173/full
Ramucirumab in Indian Patients with Advanced Gastric Cancer-Does Borderline Performance Status and Heavy Burden of Disease in Real World Practice Impact Clinical Benefit?
Background Ramucirumab is considered a standard of care as second-line therapy (CT2) in advanced gastric cancers (AGCs). The aim of this study was to assess practice patterns and outcomes with ramucirumab ..... see more
Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1728980
Conclusions: Ramucirumab appears to have similar efficacy in Indian AGC patients when compared with real-world data from other countries in terms of median EFS, but OS appears inferior due to more patients having borderline ECOG PS and high metastatic disease burden. GI hemorrhages appear more common than published data, although not...
Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy - BMC Cancer
Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2
Efficacy and safety of second-line therapy with apatinib combined with chemotherapy as second-line therapy in advanced gastric cancer: a single-arm, open-label, prospective, multicenter study
Yan Zhang,# 1 , # Junying Xu,# 2 , # Qiong Wang,# 3 , # Guohong Ling, 4 Yong Mao, 5 Maohuai Cai, 6 Yang Yang, 7 Jingfeng Mei, 1 ..... see more
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263772/
Ophthalmoplegia in a Her2+ and β-hCG+ Patient With Leptomeningeal Carcinomatosis Secondary to Gastric Adenocarcinoma
Leptomeningeal carcinomatosis (LMC) is an uncommon and devastating late complication of metastatic malignancy that carries a poor prognosis, typically faring worse when secondary to solid tumors. Diagnosis of LMC can ..... see more
Research on the Mechanism and Prevention of Hypertension Caused by Apatinib Through the RhoA/ROCK Signaling Pathway in a Mouse Model of Gastric Cancer
Hypertension is one of the main adverse effects of antiangiogenic tumor drugs and thus limits their application. The mechanism of hypertension caused by tyrosine kinase inhibitors (TKIs) targeting vascular endothelial ..... see more
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.873829/full
Relevance: The expression of RhoA/ROCK pathway-related proteins and relative mRNA levels in mice after apatinib intervention were analyzed by various methods, and blood pressure and cardiac function indexes were compared. Endothelial and cardiac function and collagen levels in the aorta were also measured to assess vascular and cardiac fibrosis...
Transcriptome sequencing of LMP2A-transfected gastric cancer cells identifies potential biomarkers in EBV-associated gastric cancer - Virus Genes
Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A ..... see more
Source : https://link.springer.com/article/10.1007/s11262-022-01925-5
Relevance: Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A (LMP2A) is an EBV latency-associated protein expressed in part of EBVaGC cases. This study analyzed the...
MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways - PubMed
doi: 10.1007/s12094-022-02862-3. Online ahead of print. 1 Department of Medical Oncology, Hangzhou Cancer Hospital, 34 Yanguan Lane, Shangcheng District, Hangzhou, 310000, Zhejiang, China. 2 Department of Medical Oncology, Hangzhou Cancer ..... see more
Understanding the association between clinical staging accuracy, treatment response, and survival among gastric cancer patients through Bayesian analysis - PubMed
doi: 10.1002/jso.27016. Online ahead of print. 1 Department of Medicine, Epidemiology, and Population Sciences, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. 2 Department of ..... see more
Evaluating Alternative Ramucirumab Doses as a Single Agent or with Paclitaxel in Second-Line Treatment of Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma: Results from Two Randomized, Open-Label, Phase II Studies - PubMed
Studies JVDB and JVCZ examined alternative ramucirumab dosing regimens as monotherapy or combined with paclitaxel, respectively, in patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. For JVDB, randomized patients ( N ..... see more
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Key Points • Source: Current Issues in Molecular Biology • Conclusion: “The results of the presented research suggest a significant role of VEGF and CXCR4 in the biology of gastric cancer. The possible predictive Show More