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Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy - PubMed

In this review, we highlight recent clinical trial data reported in the literature dealing with different ways to target various carcinogens in gastric cancer. Moreover, we touch upon other multidisciplinary ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36149600/


Conclusions: In this review, we highlight recent clinical trial data reported in the literature dealing with different ways to target various carcinogens in gastric cancer. Moreover, we touch upon other multidisciplinary therapeutic approaches such as surgery, adjuvant and neoadjuvant chemotherapy. Rational clinical trials focusing on...

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Laparoscopic total gastrectomy for concurrent gastric cancer and complete agenesis of the dorsal pancreas - PubMed

We present an unusual case of laparoscopic total gastrectomy with lymph node dissection in a 56-year-old woman with gastric cancer and agenesis of the dorsal pancreas (ADP). Esophagogastroduodenoscopy revealed erosive ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36148900/


Conclusion: Laparoscopic surgery, with careful preoperative anatomic evaluation, can be considered for concurrent gastric cancer and ADP.

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Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer - Annals of Surgical Oncology

Background Some reports showed the immune tolerance of soluble human leukocyte antigen E (HLA-E), but the role that soluble HLA-E plays in gastric cancer (GC) is unknown. We aimed to ..... see more

Source : https://link.springer.com/article/10.1245/s10434-022-12505-0


Conclusions: HLA-E expression dynamically changes on GC cells and in conditioned medium. Furthermore, soluble HLA-E can contribute to immune escape in GC cell lines, which may have significance in clinical practice. Moreover, soluble HLA-E may be a potential prognostic biomarker.

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Correlation Between Tumor Response and Survival Outcomes in Patients with Advanced Gastric Cancer Receiving Ramucirumab and Paclitaxel as Second-Line Therapy - Journal of Gastrointestinal Cancer

Background Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. The first-line treatment for GC is a combination of platinum and fluoropyrimidine-based therapy. Based on the ..... see more

Source : https://link.springer.com/article/10.1007/s12029-022-00865-5


Conclusion: Treatment with ramucirumab plus paclitaxel yielded the highest overall response rate reported to date for patients with previously treated advanced GC. In our experience, the initial tumor response is associated with a greater survival benefit which could be further improved by the identification of biomarkers predicting response.

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Efficacy and Safety of FOLFOX in Advanced Gastric Cancer Initially Presenting With Disseminated Intravascular Coagulation - PubMed

1 Third Department of Internal Medicine, University of Toyama, Toyama, Japan. 2 Third Department of Internal Medicine, University of Toyama, Toyama, Japan; [email protected] 3 Department of Clinical Oncology, University of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36099124/


Conclusion: FOLFOX therapy is well tolerated and effective in patients with AGC initially presenting with DIC and subsequent second-line treatment might be crucial for better prognosis.

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Family history of malignant tumor is a predictor of gastric cancer prognosis: Incorporation into a nomogram - PubMed

The purpose of this study was to investigate the impact of a family history of malignant tumor on the prognosis of patients with gastric cancer and develop a nomogram that ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36107576/


Conclusion/Relevance: The nomogram developed in this research can be used as an important tool to predict the prognosis of gastric cancer patients with family history data.

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Tumor-infiltrating CD226+CD8+ T cells are associated with postoperative prognosis and adjuvant chemotherapeutic benefits in gastric cancer patients - Journal of Cancer Research and Clinical Oncology

Purpose Defining the phenotypic characteristics of CD8+ T cell subsets in gastric cancer (GC) can help remodel the immune microenvironment of the tumor, thereby improving patient prognosis. CD226 has recently ..... see more

Source : https://link.springer.com/article/10.1007/s00432-022-04346-x


Conclusion: CD226 CD8 T cells may represent a novel therapeutic target and a useful marker of prognosis and therapeutic response in patients with GC.

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Proteogenomic analysis in an early onset diffuse gastric cancer patient revealed alterations in PIK3R1, TP53, SMAD4 and a potential role of the PI3K-AKT and EGFR pathways: a case report

Typically, early-onset gastric cancers (EOGC) present at the age of 45 years old or younger. Although its prevalence ranges from 2.7% to 15% depending on the population being studied, it ..... see more

Source : https://jgo.amegroups.com/article/view/65385/html


Conclusions: As explained above EOGC is a growing health concern that affects young individuals. Furthermore, the reported case displayed a poor response to standard therapy including checkpoint inhibitors and chemotherapy despite the presence of biomarkers that predict a favorable outcome. Future studies should adopt alternative approaches to...

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Differences in Pretreatment Frailty Across Gastrointestinal Cancers in Older Adults: Results From the Cancer and Aging Resilience Evaluation Registry

PURPOSE: Frailty predicts poor outcomes in older adults with cancer, but how it differs between different cancer types is unknown. We examined differences in pretreatment frailty between colorectal (CRC), pancreatic, ..... see more

Source : https://ascopubs.org/doi/abs/10.1200/OP.22.00270


Conclusion: Screening and intervention on FT for patients with hematologic malignancies is associated with increased quality of life and survival.

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Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection

Comparing Different Anesthesia Methods on Anesthetic Effect and Postoperative Pain in Patients with Early Gastric Cancer during Endoscopic Submucosal Dissection: Endoscopic submucosal dissection (ESD) is a minimally invasive technique to ..... see more

Source : https://www.hindawi.com/journals/jo/2022/7299360/


Conclusion: Compared with simple intravenous general anesthesia, intravenous combined inhalation general anesthesia can better maintain the intraoperative hemodynamic stability of patients with early gastric cancer, shorten the postoperative recovery time, and reduce the postoperative pain. On the other hand, this study is a retrospective...

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A predictive model for early death in elderly patients with gastric cancer: A population-based study

BackgroundThe mean age of gastric cancer (GC) patients has increased due to the aging society. Elderly GC patients with poor physical status tend to develop complications during the treatment courses, ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.972639/full


Conclusions: These nomogram models were considered a practical tool to identify the early death of elderly GC patients and help provide a more individualized treatment strategy.

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Gut Microbiota Dysbiosis in the Development and Progression of Gastric Cancer

Gut Microbiota Dysbiosis in the Development and Progression of Gastric Cancer: Objectives . This study aims to explore gut microbiota dysbiosis in the histological stages of gastric cancer (GC). Methods ..... see more

Source : https://www.hindawi.com/journals/jo/2022/9971619/


Conclusions: We identified differences in microbial compositional changes across stages of GC. Six genera and two metabolic pathways were more abundant in the GC group than noncancer groups, suggesting that these findings may contribute to the therapy strategies in GC in the near feature.

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European-Australasian consensus on the management of advanced gastric and gastro-oesophageal junction cancer: current practice and new directions

Gastric carcinoma and gastro-oesophageal junction (GC/GEJ) carcinoma remain a significant global problem, with patients presenting with symptoms often found to have advanced or metastatic disease. Treatment options for these patients ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425884/


Conclusion/Relevance: In this review, we highlight the positive evidence from key trials that have led to our current practice algorithm, with particular focus on the refractory advanced disease setting, discussing the areas of active research and highlighting the factors, including biomarkers and the influence of ethnicity, that contribute to...

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  • September 07, 2022
    Key Points • Source: Therapeutic Advances in Medical Oncology • Conclusion: “In this review, we highlight the positive evidence from key trials that have led to our current practice algorithm, with particular focus on Show More
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Machine learning: A non-invasive prediction method for gastric cancer based on a survey of lifestyle behaviors

Gastric cancer remains an enormous threat to human health. It is extremely significant to make a clear diagnosis and timely treatment of gastrointestinal tumors. The traditional diagnosis method (endoscope, surgery, ..... see more

Source : https://www.frontiersin.org/articles/10.3389/frai.2022.956385/full


Conclusion/Relevance: This work aims to construct a cheap, non-invasive, rapid, and high-precision gastric cancer diagnostic model using personal behavioral lifestyles and non-invasive characteristics. A retrospective study was implemented on 3,630 participants. The developed models (extreme gradient boosting, decision tree, random forest, and...

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Deep learning captures selective features for discrimination of microsatellite instability from pathologic tissue slides of gastric cancer - PubMed

Microsatellite instability (MSI) status is an important prognostic marker for various cancers. Furthermore, because immune checkpoint inhibitors are much more effective in tumors with high level of MSI (MSI-H), MSI ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36054320/


Conclusion: These results indicate that DL could automatically learn the optimal features for discrimination of MSI status in GC tissue slides. This study demonstrated the potential of a DL-based MSI classifier as a screening tool for definitive cases.

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Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF-β/Smad pathway - PubMed

Gastric cancer (GC) is one of the most prevalent malignancies of the digestive tract. Ginsenoside Rh1 was reported to exert effects on GC. The current study set out to explore ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36054718/


Conclusion: Collectively, our findings highlighted that ginsenoside Rh1 inhibited GC cell growth and tumour growth in xenograft tumour models via inhibition of the TGF-β/Smad pathway.

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Very Early Recurrence After Curative-Intent Surgery for Gastric Adenocarcinoma - Annals of Surgical Oncology

Background Recurrence after curative-intent surgery can occur in more than 50% of gastric cancer (GC) patients. We sought to identify predictors of very early recurrence (VER) among GC patients who ..... see more

Source : https://link.springer.com/article/10.1245/s10434-022-12434-y


Conclusion: One in 6 patients experienced VER following curative-intent surgery for GC. Nomograms to predict risk of VER performed well on internal validation, and stratified patients into distinct prognostic groups relative to 6- and 12-months recurrence.

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Trends in Use of Granulocyte Colony-Stimulating Factor Following Introduction of Biosimilars Among Adults With Cancer and Commercial or Medicare Insurance From 2014 to 2019 - PubMed

1 Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville. 2 Center for Drug Evaluation and Safety, University of Florida, Gainesville. 3 College of Medicine, University ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/34812849/


Conclusions and Relevance: This cross-sectional study found that utilization of G-CSFs increased among patients with cancer with high FN risk in both a commercially and Medicare-insured population, but 14% to 17% of patients still did not receive preventive treatment.

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Efficacy and safety of Nivolumab in patients with advanced esophageal, gastroesophageal, and gastric cancers; A meta-analysis of randomized controlled trials - PubMed

Compared to standard chemotherapy, the use of Nivolumab in patients with advanced esophageal, gastroesophageal, and gastric cancers is associated with improved overall and progression-free survival, with similar rates of AE ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36017642/


Conclusions: Compared to standard chemotherapy, the use of Nivolumab in patients with advanced esophageal, gastroesophageal, and gastric cancers is associated with improved overall and progression-free survival, with similar rates of AE and AE leading to death. The improvement in survival was significant in patients with ≥1% PD L1 expression.