The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more
A 69-year-old man with a known history of gastric and prostate adenocarcinoma was referred to 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging due to biochemical recurrence of prostate cancer. 68Ga-PSMA ..... see more
To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more
Source : https://www.hindawi.com/journals/cjgh/2022/5415758/
Relevance: In this study, we outlined a novel stratification method including systematic pathway activity changes of gene sets in both tumor tissues and nontumor tissues and provided a more accurate prognostic model based on least absolute shrinkage and selection operator (LASSO) regression for patients with gastric cancer, which might help to...
Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2
Obesity is a risk factor for various types of cancer. Leptin, an adipocyte‑derived hormone, may stimulate the proliferation of gastric cancer cells. However, the effect of leptin and underlying mechanism ..... see more
Source : https://www.spandidos-publications.com/10.3892/or.2022.8377
Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common malignant tumor originating from the gastrointestinal epithelium. Although the pathogenesis of GIC has not been fully elucidated, angiogenesis ..... see more
The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more
To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more
Source : https://www.hindawi.com/journals/cjgh/2022/5415758/
Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more
Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more
Conclusions: The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk assessment of gastric precancerous lesions. The role of new gastric cancer screening score system in future gastric precancerous lesions screening and high risk population identifying was promising.
BackgroundThe burden of care continues to rise considerably worldwide and the challenge of diversity in cancer research has become important. We aimed to examine trends of cancer care utilization and ..... see more
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.862173/full
Background Ramucirumab is considered a standard of care as second-line therapy (CT2) in advanced gastric cancers (AGCs). The aim of this study was to assess practice patterns and outcomes with ramucirumab ..... see more
Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1728980
Conclusions: Ramucirumab appears to have similar efficacy in Indian AGC patients when compared with real-world data from other countries in terms of median EFS, but OS appears inferior due to more patients having borderline ECOG PS and high metastatic disease burden. GI hemorrhages appear more common than published data, although not...
Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more
Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2
Yan Zhang,# 1 , # Junying Xu,# 2 , # Qiong Wang,# 3 , # Guohong Ling, 4 Yong Mao, 5 Maohuai Cai, 6 Yang Yang, 7 Jingfeng Mei, 1 ..... see more
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263772/
Leptomeningeal carcinomatosis (LMC) is an uncommon and devastating late complication of metastatic malignancy that carries a poor prognosis, typically faring worse when secondary to solid tumors. Diagnosis of LMC can ..... see more
Hypertension is one of the main adverse effects of antiangiogenic tumor drugs and thus limits their application. The mechanism of hypertension caused by tyrosine kinase inhibitors (TKIs) targeting vascular endothelial ..... see more
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.873829/full
Relevance: The expression of RhoA/ROCK pathway-related proteins and relative mRNA levels in mice after apatinib intervention were analyzed by various methods, and blood pressure and cardiac function indexes were compared. Endothelial and cardiac function and collagen levels in the aorta were also measured to assess vascular and cardiac fibrosis...
Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A ..... see more
Source : https://link.springer.com/article/10.1007/s11262-022-01925-5
Relevance: Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A (LMP2A) is an EBV latency-associated protein expressed in part of EBVaGC cases. This study analyzed the...
doi: 10.1007/s12094-022-02862-3. Online ahead of print. 1 Department of Medical Oncology, Hangzhou Cancer Hospital, 34 Yanguan Lane, Shangcheng District, Hangzhou, 310000, Zhejiang, China. 2 Department of Medical Oncology, Hangzhou Cancer ..... see more
doi: 10.1002/jso.27016. Online ahead of print. 1 Department of Medicine, Epidemiology, and Population Sciences, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. 2 Department of ..... see more
Studies JVDB and JVCZ examined alternative ramucirumab dosing regimens as monotherapy or combined with paclitaxel, respectively, in patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. For JVDB, randomized patients ( N ..... see more
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Key Points • Source: Current Issues in Molecular Biology • Conclusion: “The results of the presented research suggest a significant role of VEGF and CXCR4 in the biology of gastric cancer. The possible predictive Show More