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The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression - PubMed

The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35877436/


Conclusion: VEGF and CXCR4 play an important role in tumor progression. Their overexpression correlates with a bad prognosis and may improve high-risk patient selection, and these patients may obtain additional survival benefits if treated more aggressively.

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  • August 08, 2022
    Key Points • Source: Current Issues in Molecular Biology • Conclusion: “The results of the presented research suggest a significant role of VEGF and CXCR4 in the biology of gastric cancer. The possible predictive Show More
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68Ga-PSMA Uptake in Brain Metastasis of Gastric Carcinoma - PubMed

A 69-year-old man with a known history of gastric and prostate adenocarcinoma was referred to 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging due to biochemical recurrence of prostate cancer. 68Ga-PSMA ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35930713/


Relevance: This case reminds us of the variable spectrum of 68Ga-PSMA uptake in prostatic and nonprostatic metastatic lesions, the potential pitfalls on PET/CT images in the workup of patients with concomitant malignancies.

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Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer

To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more

Source : https://www.hindawi.com/journals/cjgh/2022/5415758/


Relevance: In this study, we outlined a novel stratification method including systematic pathway activity changes of gene sets in both tumor tissues and nontumor tissues and provided a more accurate prognostic model based on least absolute shrinkage and selection operator (LASSO) regression for patients with gastric cancer, which might help to...

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Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy - BMC Cancer

Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more

Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2


Discussion: The results of this trial will indicate whether the ramucirumab with irinotecan regimen has the potential to be a recommended treatment regimen for patients with recurrence gastric cancer during or within 6 months after the completion of adjuvant docetaxel plus S-1 therapy.

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Leptin stimulates migration and invasion and maintains cancer stem‑like properties in gastric cancer cells

Obesity is a risk factor for various types of cancer. Leptin, an adipocyte‑derived hormone, may stimulate the proliferation of gastric cancer cells. However, the effect of leptin and underlying mechanism ..... see more

Source : https://www.spandidos-publications.com/10.3892/or.2022.8377


Conclusion: The present findings support an adverse effect of obesity in gastric cancer. Consequently, targeting of leptin‑associated signaling pathways may have therapeutic potential for gastric cancer.

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Pull the plug: Anti-angiogenesis potential of natural products in gastrointestinal cancer therapy - PubMed

Gastrointestinal cancer (GIC), including gastric cancer and colorectal cancer, is a common malignant tumor originating from the gastrointestinal epithelium. Although the pathogenesis of GIC has not been fully elucidated, angiogenesis ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35871532/


Relevance: This review examines the anti-angiogenesis potential of natural products in the GIC treatment and provides clues to the development of vascular targeted agents.

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The Expression and Prognostic Significance of VEGF and CXCR4 in Gastric Cancer: Correlation with Angiogenesis, Lymphangiogenesis and Progression - PubMed

The cellular response to hypoxia includes the expression of hypoxia-inducible factor-1 (HIF-1) and its target genes: vascular endothelial growth factor (VEGF) and CXC chemokine receptor 4 (CXCR4). The aim of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35877436/


Conclusion: VEGF and CXCR4 play an important role in tumor progression. Their overexpression correlates with a bad prognosis and may improve high-risk patient selection, and these patients may obtain additional survival benefits if treated more aggressively.

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Delineating Molecular Subtypes through Gene Set Variation Analysis Confers Therapeutic and Prognostic Capability in Gastric Cancer

To claim the features of nontumor tissue in gastric cancer patients, especially in those who have undergone gastrectomy, and to identify the molecular subtypes, we collected the immunogenic and hallmark ..... see more

Source : https://www.hindawi.com/journals/cjgh/2022/5415758/


Conclusion: Our study created lasting value beyond molecular subtypes and underscored the significance of normal tissues in gastric cancer development, which drawn a novel prognostic model for gastric treatment.

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The application of new gastric cancer screening score system for gastric cancer screening and risk assessment of gastric precancerous lesions in China - PubMed

Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35868004/

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  • July 25, 2022
    Key Points • Source: Scandinavian Journal of Gastroenterology • Conclusion: “The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk Show More
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The application of new gastric cancer screening score system for gastric cancer screening and risk assessment of gastric precancerous lesions in China - PubMed

Objective: To evaluate the value of new gastric cancer screening score system for risk assessment of gastric precancerous lesions. Methods: A total of 520 patients were enrolled after the examination ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35868004/


Conclusions: The new gastric cancer screening score system is closely linked with histological OLGA/OLGIM staging system in the risk assessment of gastric precancerous lesions. The role of new gastric cancer screening score system in future gastric precancerous lesions screening and high risk population identifying was promising.

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Health Care Utilization and Anti-Cancer Drug Expenditure for Six Solid Cancers in Korea From 2007 to 2019

BackgroundThe burden of care continues to rise considerably worldwide and the challenge of diversity in cancer research has become important. We aimed to examine trends of cancer care utilization and ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.862173/full


Conclusion/Relevance: The anti-cancer drugs with the largest market shares were ramucirumab for gastric cancer; oxaliplatin for colorectal cancer; sorafenib for liver cancer; pembrolizumab, nivolumab, for lung cancer; trastuzumab for breast cancer; and bicalutamide for prostate cancer.

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Ramucirumab in Indian Patients with Advanced Gastric Cancer-Does Borderline Performance Status and Heavy Burden of Disease in Real World Practice Impact Clinical Benefit?

Background Ramucirumab is considered a standard of care as second-line therapy (CT2) in advanced gastric cancers (AGCs). The aim of this study was to assess practice patterns and outcomes with ramucirumab ..... see more

Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0041-1728980


Conclusions: Ramucirumab appears to have similar efficacy in Indian AGC patients when compared with real-world data from other countries in terms of median EFS, but OS appears inferior due to more patients having borderline ECOG PS and high metastatic disease burden. GI hemorrhages appear more common than published data, although not...

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Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy - BMC Cancer

Background Although docetaxel plus S-1 adjuvant chemotherapy after gastrectomy with D2 lymphadenectomy has been a standard of treatment for stage III gastric cancer, there is no established chemotherapy for patients ..... see more

Source : https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09844-2


Discussion: The results of this trial will indicate whether the ramucirumab with irinotecan regimen has the potential to be a recommended treatment regimen for patients with recurrence gastric cancer during or within 6 months after the completion of adjuvant docetaxel plus S-1 therapy.

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Conclusions: The combination of apatinib and chemotherapy demonstrated clinical activity and acceptable toxicity as a second-line treatment for advanced GC, and may provide new second-line treatment options for advanced GC patients.

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Ophthalmoplegia in a Her2+ and β-hCG+ Patient With Leptomeningeal Carcinomatosis Secondary to Gastric Adenocarcinoma

Leptomeningeal carcinomatosis (LMC) is an uncommon and devastating late complication of metastatic malignancy that carries a poor prognosis, typically faring worse when secondary to solid tumors. Diagnosis of LMC can ..... see more

Source : https://www.cureus.com/articles/102119-ophthalmoplegia-in-a-her2-and--hcg-patient-with-leptomeningeal-carcinomatosis-secondary-to-gastric-adenocarcinoma


Relevance: In this report, we present a case of LMC secondary to metastatic gastric adenocarcinoma in a patient whose only manifestation was cranial nerve palsies, and whose cancer was also found to be Her2 and β-hCG positive, two markers not widely recognized in gastric cancer.

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Research on the Mechanism and Prevention of Hypertension Caused by Apatinib Through the RhoA/ROCK Signaling Pathway in a Mouse Model of Gastric Cancer

Hypertension is one of the main adverse effects of antiangiogenic tumor drugs and thus limits their application. The mechanism of hypertension caused by tyrosine kinase inhibitors (TKIs) targeting vascular endothelial ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.873829/full


Relevance: The expression of RhoA/ROCK pathway-related proteins and relative mRNA levels in mice after apatinib intervention were analyzed by various methods, and blood pressure and cardiac function indexes were compared. Endothelial and cardiac function and collagen levels in the aorta were also measured to assess vascular and cardiac fibrosis...

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Transcriptome sequencing of LMP2A-transfected gastric cancer cells identifies potential biomarkers in EBV-associated gastric cancer - Virus Genes

Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A ..... see more

Source : https://link.springer.com/article/10.1007/s11262-022-01925-5


Relevance: Epstein-barr virus (EBV) is a well-known human oncogenic virus. However, its molecular mechanisms in the initiation and development of EBV-associated gastric cancer (EBVaGC) remain poorly understood. Latent membrane protein 2A (LMP2A) is an EBV latency-associated protein expressed in part of EBVaGC cases. This study analyzed the...

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MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways - PubMed

doi: 10.1007/s12094-022-02862-3. Online ahead of print. 1 Department of Medical Oncology, Hangzhou Cancer Hospital, 34 Yanguan Lane, Shangcheng District, Hangzhou, 310000, Zhejiang, China. 2 Department of Medical Oncology, Hangzhou Cancer ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35819589/


Conclusions: In conclusion, it suggests that miR-507 could inhibit the progression of GC via regulating CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways.

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Understanding the association between clinical staging accuracy, treatment response, and survival among gastric cancer patients through Bayesian analysis - PubMed

doi: 10.1002/jso.27016. Online ahead of print. 1 Department of Medicine, Epidemiology, and Population Sciences, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. 2 Department of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35819061/


Conclusions: NAT is associated with improved survival for GC, but it seems to be contingent on treatment response among patients with intermediate-stage disease.

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Evaluating Alternative Ramucirumab Doses as a Single Agent or with Paclitaxel in Second-Line Treatment of Locally Advanced or Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma: Results from Two Randomized, Open-Label, Phase II Studies - PubMed

Studies JVDB and JVCZ examined alternative ramucirumab dosing regimens as monotherapy or combined with paclitaxel, respectively, in patients with advanced/metastatic gastric/gastroesophageal junction (GEJ) adenocarcinoma. For JVDB, randomized patients ( N ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35267477/


Conclusion: The lack of a dose/exposure-response relationship in these studies supports the standard dose of ramucirumab 8 mg/kg-Q2W as monotherapy or in combination with paclitaxel as second-line treatment for advanced/metastatic gastric/GEJ adenocarcinoma.