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Switching from One Biosimilar to Another Biosimilar of the Same Reference Biologic: A Systematic Review of Studies - BioDrugs

Switching from One Biosimilar to Another Biosimilar of the Same Reference Biologic: A Systematic Review of Studies - BioDrugs

Source :

https://link.springer.com/article/10.1007/s40259-022-00546-6

Background Multiple switches (transitions) between biosimilars of the same reference biologic are now a reality, and they are expected to become more common in the future as more biosimilars enter the market. Switching between two biosimilars of the same reference biologic is generally driven by affordability, formulary requirements, or the relocation/travel of the patient.


Conclusion: Within the limitations of this systematic review, available data suggests that biosimilar-to-biosimilar switching is a safe and effective clinical practice, although it is not covered by current health authority regulations or guidance. No reduction in effectiveness or increase in adverse events was detected in biosimilar-to-biosimilar switching studies conducted to date.