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Navigating the HER2-Low Paradigm in Breast Oncology: New Standards, Future Horizons - PubMed

Navigating the HER2-Low Paradigm in Breast Oncology: New Standards, Future Horizons - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35856622/

The confirmation of the HER2-low paradigm is expected to have a major impact in breast oncology. About half of all breast cancers harbor HER2-low expression, which can be targeted with the anti-HER2 antibody-drug conjugate trastuzumab deruxtecan (T-DXd), leading to a relevant survival benefit in the ...


Conclusion/Relevance: In this article, we recapitulate the current knowledge on HER2-low breast cancer, discussing whether it should be considered a distinct subtype, how it should be implemented in the clinic, and how its definition may evolve in the coming years with the evolution of our clinical and translational knowledge.