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Immunological Landscape of HER-2 Positive Breast Cancer - PubMed

Immunological Landscape of HER-2 Positive Breast Cancer - PubMed

Source :

https://pubmed.ncbi.nlm.nih.gov/35804943/

Understanding the biological aspects of immune response in HER2+ breast cancer is crucial to implementing new treatment strategies in these patients. It is well known that anti-HER2 therapy has improved survival in this population, yet a substantial percentage may relapse, creating a need within the ...


Relevance: This systematic review indicates the immunological mechanisms through which trastuzumab and other agents target cancer cells, also outlining the main trials studying immune checkpoint blockade. Finally, we report on anti-HER2 vaccines and include a figure exemplifying their mechanisms of action.