Next-generation Bruton's tyrosine kinase (BTK) inhibitors potentially targeting BTK C481S mutation- Recent developments and Perspectives - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35927919/
Bruton's tyrosine kinase (BTK) plays a vital role in B-cell antigen receptor (BCR) signalling transduction pathway. Controlling BCR signalling by BTK inhibitors is a promising therapeutic approach for the treatment of inflammatory and autoimmune diseases. Since the approval of ibrutinib for the trea ...
Relevance: In this review, we summarized the discovery and development of next-generation BTK inhibitors, specially targeting to BTK C481S mutation and their applications for the treatment of lymphomas and autoimmune diseases.