Dual Targeting of Anti-Apoptotic Proteins Enhances Chemosensitivity of the Acute Myeloid Leukemia Cells
Source : https://journal.waocp.org/article_90207.html
Document Type : Research Articles Authors 1 Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran. 2 Department of Immunology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. 3 Department of Medical Laboratory Sciences, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
Conclusions: Our investigation suggests that suppression of Mcl-1 and survivin by siRNA can effectually inhibit cell growth and overcome chemoresistance of AML cells. Therefore siRNAs may be an important adjuvant in chemotherapy for AML patients.