Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function - PubMed

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35845214/

All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK-1026. The mechanism underlying increased bleeding tendency with Btk inhibitors remains unclear ...


Conclusion: As MK-1026 showed less off-target effects and only affected activation of isolated platelets, it might be promising for future treatment.