The immunosuppressant drug Cyclosporin A aggravates irradiation effects in endothelial cells - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35272142/
The immunosuppressant drug Cyclosporin A (CsA) has been widely used to prevent the development of Graft-versus-Host Disease (GvHD) that can occur after transplantation, including allogeneic graft after accidental high-dose irradiation in humans. Here, we show that CsA alone stimulates ICAM-1 overexp ...
Conclusions: Altogether, these results suggest that post-transplant CsA treatment may exacerbate the deleterious effects of irradiation on the endothelium.