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Human cytomegalovirus-specific T-cell reconstitution and late-onset cytomegalovirus infection in hematopoietic stem cell transplant recipients following letermovir prophylaxis - PubMed

Human cytomegalovirus-specific T-cell reconstitution and late-onset cytomegalovirus infection in hematopoietic stem cell transplant recipients following letermovir prophylaxis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35042012/

1 Microbiology and Virology Unit, IRCCS Policlinico San Matteo, Pavia, Italy. 2 Molecular Medicine Department, University of Pavia, Pavia, Italy. 3 Hematology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 4 Clinical Epidemiology and Biometry Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 5 Microbiology and Virology Unit, IRCCS Policlinico San Matteo, Pavia, Italy.


Conclusions: LTV prophylaxis delays HCMV infection and HCMV-specific immune reconstitution, therefore immunological and virological monitoring should be implemented post-prophylaxis discontinuation. The potential effect of LTV prophylaxis in reducing chronic GvHD should be evaluated by prospective studies.